ArticleCell reports2020
Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Representations of Subsecond Duration-Based Timing by Complex Spike Synchrony in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Self-timed movement initiation requires rapid sequential coordination of circuits in prefrontal cortex and cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Neural circuits encode prior knowledge of temporal statistics.Nature neuroscience · 2026Article
- Cerebellum violates Marr-Albus predictions to train synapses on long-term anticipatory goals.bioRxiv : the preprint server for biology · 2026Article
- A cerebello-thalamo-cortical pathway transmits reward-based post-error signals for motor timing correction during learning in male mice.Nature communications · 2025Article
- Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning.PLoS computational biology · 2025Article
- Control of tongue movements by the Purkinje cells of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (bioRxiv : the preprint server for biology · 2024Article
- An output-null signature of inertial load in motor cortex.Nature communications · 2024Article
- Article
- Complex spikes perturb movements and reveal the sensorimotor map of Purkinje cells.Current biology : CB · 2023Article
- An output-null signature of inertial load in motor cortex.bioRxiv : the preprint server for biology · 2023Article
- Article
- Electrophysiological activity from over the cerebellum and cerebrum during eye blink conditioning in human subjects.Physiological reports · 2023Article
- Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz.Biomedicines · 2022Article
- Optical Fiber-Based Recording of Climbing Fiber CaBiology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that requires mice to rapidly discriminate between multisensory and unisensory stimuli before motor initiation. Neuropixels recordings show that both sensory stimuli and motor initiation are represented by short-latency simple spikes. Optogenetic manipulation of short-latency simple spikes abolishes or delays motor initiation in a rate-dependent manner, indicating a role in motor initiation and its timing. Two-photon calcium imaging reveals task-related coherence of complex spikes organized into conserved alternating parasagittal stripes. The coherence of sensory-evoked complex spikes increases with learning and correlates with enhanced temporal precision of motor initiation. These results suggest that both simple spikes and complex spikes govern sensory-driven motor initiation: simple spikes modulate its latency, and complex spikes refine its temporal precision, providing specific cellular substrates for cerebellar sensorimotor control.
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