ArticleeLife2020
Canonical goal-selective representations are absent from prefrontal cortex in a spatial working memory task requiring behavioral flexibility.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Model Systems infrastructure of the German Center for Mental Health (DZPG): toward an integrated, mechanism-based framework for mental health research.European archives of psychiatry and clinical neuroscience · 2026Review
- Density-based longitudinal neuron tracking in high-density electrophysiological recordings.Patterns (New York, N.Y.) · 2026Article
- Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.Nature communications · 2026Article
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- The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex.PLoS biology · 2025Article
- Divergent subregional information processing in mouse prefrontal cortex during working memory.Communications biology · 2024Article
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- Divergent Subregional Information Processing in Mouse Prefrontal Cortex During Working Memory.bioRxiv : the preprint server for biology · 2024Article
- A goal pointer for a cognitive map in the orbitofrontal cortex.Current opinion in neurobiology · 2023Review
- Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience.bioRxiv : the preprint server for biology · 2023Article
- A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory.Nature communications · 2022Article
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The prefrontal cortex (PFC)'s functions are thought to include working memory, as its activity can reflect information that must be temporarily maintained to realize the current goal. We designed a flexible spatial working memory task that required rats to navigate - after distractions and a delay - to multiple possible goal locations from different starting points and via multiple routes. This made the current goal location the key variable to remember, instead of a particular direction or route to the goal. However, across a broad population of PFC neurons, we found no evidence of current-goal-specific memory in any previously reported form - that is differences in the rate, sequence, phase, or covariance of firing. This suggests that such patterns do not hold working memory in the PFC when information must be employed flexibly. Instead, the PFC grouped locations representing behaviorally equivalent task features together, consistent with a role in encoding long-term knowledge of task structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.