Evidence map›Paper›PMID 33357351›Full record

ArticleDeutsches Arzteblatt international2020

Frailty as a Prognostic Indicator in Intensive Care.

Christian Jung, Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Michael Beil, Malte Kelm

Abstract read
In one paragraph

Article in Deutsches Arzteblatt international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. [Frailty in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. [Core curriculum of intensive care and emergency medicine in internal medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
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  12. Article
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  14. Article
  15. Article
  16. Article
  17. Article
  18. [Clinical importance of the detection of frailty].Zeitschrift fur Gerontologie und Geriatrie · 2021
    Article
  19. [COVID-19 in old age-The geriatric perspective].Zeitschrift fur Gerontologie und Geriatrie · 2021
    Review
  20. [Geriatric patients in the intensive care unit].Der Gastroenterologe : Zeitschrift fur Gastroenterologie und Hepatologie · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christian JungDepartment of Cardiology, Pulmonary Diseases and Vascular Medicine, Faculty of Medicine, Düsseldorf University Hospital; Department of Internal Medicine II, Paracelsus Medical University, Salzburg, Austria Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Intensive Care Medicine, Hadassah-Hebrew University Hospital, Jerusalem, Israel; Cardiovascular Research Institute Düsseldorf (CARID).
Raphael Romano Bruno
Bernhard Wernly
Georg Wolff
Michael Beil
Malte Kelm

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe percentage of patients in intensive care who are 80 years old or older is continually increasing. Such patients already made up more than 20% of all patients in intensive care in Germany in the years 2007-2011. Meanwhile, effective treatments that support the organs of the body and keep severely ill patients alive are also being continually developed and refined. Frailty is a key prognostic parameter. The scientifically based assessment of frailty can be highly useful in intensive care medicine with regard to consented decision-making, individualized prognostication, treatment planning, and aftercare.

methodsPertinent publications were retrieved by a selective search in the PubMed database. On the basis of the literature assessment, a variety of screening instruments were used to assess frailty and its significance for very old, critically ill patients in German intensive care units.

resultsOnly a small number of screening instruments are suitable for routine use in German intensive care units. The scores vary in diagnostic precision. The Clinical Frailty Scale (CFS) enables highly accurate prognostication; it considers the patient in relation to his or her social environment, and to the reference population. Categorization is achieved by means of pictograms that are supplemented with brief written descriptions. The CFS can be used prospectively and is easy to learn. Its interrater reliability is high (weighted Cohen's κ: 0.85 [0.84; 0.87]), and it has been validated for routine use in intensive care units in Germany.

conclusionNone of the available scores enable perfect prognostication. In Germany, frailty in intensive-care patients is currently best assessed on a simple visual scale (CFS).

Indexed as

FrailtyAged, 80 and overCritical CareFemaleGermanyHumansIntensive Care UnitsPrognosisReproducibility of Results

Identifiers

PMID33357351
PMCPMC7838379

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.