Evidence map›Paper›PMID 33357251›Full record

ArticlePublic health nutrition2021

Pre-pregnancy BMI is associated with offspring body composition in adulthood before adiposity-related disorders: a retrospective cohort.

Ilana Eshriqui, Angélica Marques Martins Valente, Luciana Dias Folchetti, Bianca de Almeida-Pititto, Sandra Roberta G Ferreira

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Caesarean section and obesity in young adult offspring: Update of a systematic review with meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
  2. Article
  3. Maternal high-fat high-sugar diet impairs bone quality and strength but not cartilage in aging mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  4. Article
  5. Associations ofFrontiers in cellular and infection microbiology · 2022
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ilana EshriquiGraduation Program in Public Health Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
Angélica Marques Martins ValenteGraduation Program in Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
Luciana Dias FolchettiSchool of Public Health, University of São Paulo, São Paulo, Brazil.
Bianca de Almeida-PitittoDepartment of Preventive Medicine, Federal University of São Paulo, São Paulo, Brazil.
Sandra Roberta G FerreiraDepartment of Epidemiology, School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, São Paulo01246-904, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the association between maternal pre-pregnancy BMI and offspring body composition in adulthood.

designRetrospective cohort. Undergraduates of nutrition or nutritionists were recruited at the baseline of the Nutritionists' Health Study between 2014 and 2017. Maternal pre-pregnancy BMI and current life aspects were self-reported through online questionnaires. Three body compartments were dual-energy x-ray absorptiometry-determined. The following variables were obtained: body fat (%), fat mass index (FMI) (kg/m2), android-to-gynoid fat ratio, visceral adipose tissue (VAT) (cm3), appendicular skeletal muscle mass index (ASMI) (kg/m2), total bone and femur mineral content (g) and density (g/cm2). Linear regression adjusted according to directed acyclic graphs recommendation was performed.

settingSão Paulo, Brazil.

participantsHealthy non-pregnant women (aged 20-45 years) (n 150).

resultsMedian age and BMI were 22 years (IQR = 20, 29) and 22·3 kg/m2 (IQR = 20·4, 25·3), respectively. Pre-pregnancy BMI ≥ 25 kg/m2 was reported by 14·7 % of mothers. In fully adjusted models, maternal pre-pregnancy BMI was associated with their daughters' body fat % (β = 0·31; 95 % CI 0·0004, 0·63), FMI (β = 0·17; 95 % CI 0·03, 0·30), android-to-gynoid ratio (β = 0·01; 95 % CI 0·004, 0·02) and VAT (β = 0·09; 95 % CI 0·02, 0·16), but not with total bone density (β = 0·001; 95 % CI -0·003, 0·006) and content (β = 7·13; 95 % CI -4·19, 18·46). Direct association with ASMI was also detected, but lost statistical significance when participants whose mothers were underweight were excluded.

conclusionsMaternal pre-pregnancy BMI was directly associated with offspring general and visceral adiposity but seems not to be associated with bone mass. Results reinforce importance of avoiding excess of maternal adiposity, as an attempt to break the vicious cycle of obesity transmission.

Indexed as

AdiposityBody CompositionAdultBody Mass IndexFemaleHumansObesityPregnancyRetrospective StudiesBody compositionOffspringPre-gestational BMIVisceral adipose tissue

Identifiers

PMID33357251
PMCPMC10195459
OpenAlexW3116988723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.