Evidence map›Paper›PMID 33357210›Full record

ArticleBosnian journal of basic medical sciences2021

Trends of incidence and prognosis of upper tract urothelial carcinoma.

Jianping Wu, Shuqiu Chen, Xiaoli Wu, Weipu Mao, Yali Wang, Bin Xu, Donghui Zheng, Ming Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bosnian journal of basic medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianping WuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu province, China.
Shuqiu ChenDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu province, China.
Xiaoli WuDepartment of Obstetrics and Gynecology, Affiliated Nanjing Maternity and Child Health Hospital, Nanjing Medical University, Nanjing, Jiangsu province, China.
Weipu MaoDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu province, China; Surgical Research Center, Institute of Urology, Southeast University Medical School, Nanjing, China; Department of Urology, Nanjing Lishui District People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.
Yali WangDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu province, China.
Bin XuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu province, China; Surgical Research Center, Institute of Urology, Southeast University Medical School, Nanjing, China; Department of Urology, Nanjing Lishui District People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.
Donghui ZhengDepartment of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu province, China.
Ming ChenDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu province, China; Surgical Research Center, Institute of Urology, Southeast University Medical School, Nanjing, China; Department of Urology, Nanjing Lishui District People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patients. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract data on UTUC patients between 1988 and 2015. Incidence was calculated using Joinpoint regression software, and trends were quantified by annual percentage change (APC). A nomogram was constructed using R software to predict the OS and CSS probabilities for individual patients. From 1988 to 2015, the incidence of UTUC showed a downward trend (1988: 1.57/100,000 to 2015: 1.51/100,000; APC=-0.1). After stratification according to sex, age and primary site, we found that the incidences of UTUC in males, patients 70+ years old and the renal pelvis were higher than those in females, patients <70 years old and ureter cancer patients. In the training cohort, the nomogram established based on multivariate Cox regression results showed better OS and CSS accuracy (OS: C-index=0.701, AUC=0.736; CSS: C-index=0.729, and AUC=0.688) than SEER stage. In addition, the calibration curves showed good consistency between the predicted and actual 3-, 5- and 10-year OS and CSS rates of the nomogram. In the past 30 years, the incidence of UTUC has shown a general downward trend, and the prognostic nomogram we established can provide a personalized risk assessment for the survival of UTUC patients.

Indexed as

AgedArea Under CurveCalibrationCarcinoma, Transitional CellFemaleHumansIncidenceMaleMiddle AgedNomogramsProbabilityPrognosisProportional Hazards ModelsRisk AssessmentSEER ProgramTreatment Outcome

Identifiers

PMID33357210
PMCPMC8381214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.