Evidence map›Paper›PMID 33357002›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Synthesis of some quinazolinones inspired from the natural alkaloid L

Mostafa M Ghorab, Maged S Abdel-Kader, Ali S Alqahtani, Aiten M Soliman

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mostafa M GhorabDepartment of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID https://orcid.org/0000-0003-4250-0452
Maged S Abdel-KaderDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Ali S AlqahtaniDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Aiten M SolimanDepartment of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID https://orcid.org/0000-0001-6562-9828

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A set of quinazolinones synthesized by the aid of L-norephedrine was assembled to generate novel analogues as potential anticancer and radiosensitizing agents. The new compounds were evaluated for their cytotoxic activity against MDA-MB-231, MCF-7, HepG-2, HCT-116 cancer cell lines and EGFR inhibitory activity. The most active compounds

Indexed as

ApoptosisBinding SitesCell LineCell ProliferationEnzyme InhibitorsEpithelial CellsErbB ReceptorsGamma RaysHCT116 CellsHep G2 CellsHumansInhibitory Concentration 50MCF-7 CellsMolecular Docking SimulationPhenylpropanolamineProtein BindingEGFR protein, humanEnzyme InhibitorsErbB ReceptorsPhenylpropanolamineQuinazolinonesRadiation-Sensitizing AgentsanticancercytotoxicitydockingEGFRQuinazolinone

Identifiers

PMID33357002
PMCPMC7781899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.