Evidence map›Paper›PMID 33356996›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2021

Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus melanocortin circuit to treat diet-induced obesity.

Niloy Jafar Iqbal, Gary J Schwartz, Hongling Zhao, Liang Zhu, Streamson Chua

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Niloy Jafar IqbalDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Gary J SchwartzDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Hongling ZhaoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Liang ZhuDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Streamson ChuaDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York.ORCID 0000-0002-9437-9925
Albert Einstein College of Medicine · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Special Animal CoreP30DK041296 · NIDDK · YESHIVA UNIVERSITY · PI GUPTA, SANJEEV · 1989 to 2018
$22.9M
pRb Function in Mediobasal Hypothalamus in Diet Induced ObesityR01DK111043 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHUA, STREAMSON C · 2016 to 2020
$2.9M
Tumor Suppressor pRb is a Novel Target for Hypothalamic Inhibition of Diet Induced ObesityF30DK116532 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI IQBAL, NILOY · 2018 to 2020
$148k
HHS | NIH | National Cancer Institute (NCI) CA013330HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK020541HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK026687HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK041296HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK111043HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK116532NCI NIH HHS P30 CA013330NIDDK NIH HHS F30 DK116532NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK041296NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK111043
6 · The paper itself

Abstract

The arcuate nucleus (ARC) of the hypothalamus comprises two antagonistic neuron populations critical for energy balance, namely, the anorexigenic pro-opiomelanocortin (POMC) and the orexigenic agouti-related peptide (AgRP) neurons that act as agonists and antagonists, respectively, for neurons expressing the type IV melanocortin receptor (MC4R) (Andermann ML and Lowell BB.

Indexed as

AnimalsArcuate Nucleus of HypothalamusCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Diet, High-FatMaleMelanocortinsMiceMice, Inbred C57BLMice, ObeseMice, TransgenicNerve NetNeuronsObesityParaventricular Hypothalamic NucleusProtein Kinase InhibitorsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6MC4R protein, mouseMelanocortinsProtein Kinase InhibitorsReceptor, Melanocortin, Type 4

Identifiers

PMID33356996
PMCPMC7988782
OpenAlexW3117406960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.