Evidence map›Paper›PMID 33356995›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2021

LRP1 regulates food intake and energy balance in GABAergic neurons independently of leptin action.

Min-Cheol Kang, Ji A Seo, Hyon Lee, Aykut Uner, Won-Mo Yang, Kellen Cristina da Cruz Rodrigues, Hyun Jeong Kim, Wendy Li, John N Campbell, Yossi Dagon and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Min-Cheol KangDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Ji A SeoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Hyon LeeDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Aykut UnerDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Won-Mo YangDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Kellen Cristina da Cruz RodriguesDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Hyun Jeong KimDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Wendy LiDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
John N CampbellDepartment of Biology, University of Virginia, Charlottesville, Virginia.
Yossi DagonDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Young-Bum KimDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-9471-6330
Beth Israel Deaconess Medical Center · USUniversity of Virginia · US

Funding

Role of tanycytic LRP in Aβ clearanceR01DK123002 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIM, YOUNG-BUM · 2020 to 2023
$2.9M
Control of Energy Balance by ApoJ SignalingR01DK106076 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIM, YOUNG-BUM · 2017 to 2020
$2.2M
ApoJ as a novel hepatokine targeting muscle glucose metabolismR01DK111529 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIM, YOUNG-BUM · 2016 to 2020
$2.2M
NIDDK NIH HHS R01 DK106076NIDDK NIH HHS R01 DK111529NIDDK NIH HHS R01 DK123002
6 · The paper itself

Abstract

Low-density lipoprotein receptor-related protein 1 (LRP1) is a member of LDL receptor family that plays a key role in systemic glucose and lipid homeostasis. LRP1 also regulates energy balance in the hypothalamus by mediating leptin's anorexigenic action, although the underlying neurocircuitry involved is still unclear. Because GABAergic neurons are a major mediator of hypothalamic leptin action, we studied the role of GABAergic LRP1 in energy balance and leptin action using mice lacking LRP1 in Vgat- or AgRP-expressing neurons (Vgat-Cre; LRP1

Indexed as

EatingEnergy MetabolismAgouti-Related ProteinAnimalsFemaleGABAergic NeuronsGlucoseHomeostasisInsulin ResistanceLeptinLow Density Lipoprotein Receptor-Related Protein-1MaleMiceMice, Inbred C57BLMice, KnockoutObesityAgouti-Related ProteinAgrp protein, mouseGlucoseLeptinLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseReceptors, LeptinAgRPfood intakeGABAergicleptinLRP1Stat3

Identifiers

PMID33356995
PMCPMC8260358
OpenAlexW3115843688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.