ArticleAmerican journal of physiology. Heart and circulatory physiology2021
Role of coronary flow regulation and cardiac-coronary coupling in mechanical dyssynchrony associated with right ventricular pacing.
Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Hierarchy Aware CT-Driven Constrained Constructive Optimization: A Framework for Coronary Network Generation.Annals of biomedical engineering · 2026Article
- Acute effects of mechanical dyssynchrony on left ventricular function and coronary perfusion.Frontiers in bioengineering and biotechnology · 2025Article
- Rapid estimation of left ventricular contractility with a physics-informed neural network inverse modeling approach.Artificial intelligence in medicine · 2024Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images.Bioengineering (Basel, Switzerland) · 2024Article
- Simulation of coronary capillary transit time based on full vascular model of the heart.Computer methods and programs in biomedicine · 2024Article
- Preconditioning with selective autoretroperfusion:Frontiers in bioengineering and biotechnology · 2024Article
- An in silico study of the effects of left ventricular assist device on right ventricular function and inter-ventricular interaction.Artificial organs · 2023Article
- Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Mechanism of exercise intolerance in heart diseases predicted by a computer model of myocardial demand-supply feedback system.Computer methods and programs in biomedicine · 2022Article
- Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model.Computers in biology and medicine · 2022Article
- A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling.Frontiers in physiology · 2022Article
- Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility.Frontiers in physiology · 2021Article
- Review of cardiac-coronary interaction and insights from mathematical modeling.WIREs mechanisms of diseaseReview
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Authors and funding
6 authors.
Funding
Abstract
Mechanical dyssynchrony (MD) affects left ventricular (LV) mechanics and coronary perfusion. To understand the multifactorial effects of MD, we developed a computational model that bidirectionally couples the systemic circulation with the LV and coronary perfusion with flow regulation. In the model, coronary flow in the left anterior descending (LAD) and left circumflex (LCX) arteries affects the corresponding regional contractility based on a prescribed linear LV contractility-coronary flow relationship. The model is calibrated with experimental measurements of LV pressure and volume, as well as LAD and LCX flow rate waveforms acquired under regulated and fully dilated conditions from a swine under right atrial (RA) pacing. The calibrated model is applied to simulate MD. The model can simultaneously reproduce the reduction in mean LV pressure (39.3%), regulated flow (LAD: 7.9%; LCX: 1.9%), LAD passive flow (21.6%), and increase in LCX passive flow (15.9%). These changes are associated with right ventricular pacing compared with RA pacing measured in the same swine only when LV contractility is affected by flow alterations with a slope of 1.4 mmHg/mL
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