Evidence map›Paper›PMID 33356953›Full record

ArticleAmerican journal of physiology. Renal physiology2021

High salt intake induces collecting duct HDAC1-dependent NO signaling.

Randee Sedaka, Kelly A Hyndman, Elena Mironova, James D Stockand, Jennifer S Pollock

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Randee SedakaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Kelly A HyndmanSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-8465-2588
Elena MironovaDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
James D StockandDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Jennifer S PollockSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · USThe University of Texas Health Science Center at San Antonio · US

Funding

Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
Renal endothelin receptor-specific function in angiotensin ll-dependent hypertensP01HL095499 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SULLIVAN, JENNIFER C · 2010 to 2014
$11.1M
Training Program in Cardiovascular PathophysiologyT32HL007918 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALLINGER, SCOTT W. · 1999 to 2018
$3.6M
Novel mechanisms of HDAC1 regulation of renal collecting duct functionK01DK105038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HYNDMAN, KELLY · 2015 to 2019
$754k
Renal implications of AQP3 lysine acetylationR03DK120503 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HYNDMAN, KELLY · 2019 to 2020
$223k
Novel Mechanisms of Nitric Oxide Activation in the KidneyF31DK111067 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SEDAKA, RANDEE · 2016 to 2018
$103k
NHLBI NIH HHS P01 HL095499NHLBI NIH HHS P01 HL136267NHLBI NIH HHS T32 HL007918NIDDK NIH HHS F31 DK111067NIDDK NIH HHS K01 DK105038NIDDK NIH HHS R03 DK120503
6 · The paper itself

Abstract

We reported that high salt (HS) intake stimulates renal collecting duct (CD) endothelin (ET) type B receptor (ET

Indexed as

NatriuresisRenal EliminationAnimalsEndothelin-1Histone Deacetylase 1Kidney Tubules, CollectingMaleMiceMice, Inbred C57BLNitric OxideNitric Oxide Synthase Type IReceptor, Endothelin BSignal TransductionSodium Chloride, DietaryEDNRB protein, mouseEndothelin-1Hdac1 protein, mouseHistone Deacetylase 1Nitric OxideNitric Oxide Synthase Type INos1 protein, mouseReceptor, Endothelin BSodium Chloride, Dietarycollecting ductHDAC1nitric oxidesalt

Identifiers

PMID33356953
PMCPMC7988806
OpenAlexW3116297993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.