Evidence map›Paper›PMID 33356823›Full record

ArticleVirulence2021

Post-translational knockdown and post-secretional modification of EsxA determine contribution of EsxA membrane permeabilizing activity for mycobacterial intracellular survival.

Yanqing Bao, Lin Wang, Jianjun Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Physiological stage-dependent effects ofFrontiers in microbiology · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yanqing BaoDepartment of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso , El Paso, Texas, USA.
Lin WangDepartment of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso , El Paso, Texas, USA.
Jianjun SunDepartment of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso , El Paso, Texas, USA.ORCID 0000-0001-9399-7644
The University of Texas at El Paso · US

Funding

TOXICOLOGY PROJECTG12RR008124 · NCRR · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 1992 to 2011
$20.8M
TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
Receptor disulfide allosteric regulation of anthrax toxin actionSC1GM095475 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI SUN, JIANJUN · 2011 to 2020
$2.6M
NCRR NIH HHS G12 RR008124NIGMS NIH HHS SC1 GM095475NIMHD NIH HHS G12 MD007592
6 · The paper itself

Abstract

Current genetic studies (e.g. gene knockout) have suggested that EsxA and EsxB function as secreted virulence factors that are essential for

Indexed as

Cell Membrane PermeabilityA549 CellsBacterial ProteinsEpithelial CellsHumansLungMacrophagesMycobacterium marinumProtein Processing, Post-TranslationalTHP-1 CellsVirulenceVirulence FactorsBacterial ProteinsVirulence Factorsesxaesxbintracellular survivalmembrane-permeabilizing activitymycobacterium marinumMycobacterium tuberculosis

Identifiers

PMID33356823
PMCPMC7808419
OpenAlexW3116867387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.