Evidence map›Paper›PMID 33356811›Full record

ArticleChannels (Austin, Tex.)2021

Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells.

Gabor Tajti, Tibor Gabor Szanto, Agota Csoti, Greta Racz, César Evaristo, Peter Hajdu, Gyorgy Panyi

Open access · goldAbstract read
In one paragraph

Article in Channels (Austin, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. Optimization ofFrontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Gabor TajtiDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen, Hungary.
Tibor Gabor SzantoDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen, Hungary.
Agota CsotiDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen, Hungary.
Greta RaczDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen, Hungary.
César EvaristoR&D Reagents Chemical Biology, Miltenyi Biotec B.V. & Co. KG , Bergisch Gladbach, Germany.
Peter HajduDepartment of Biophysics and Cell Biology, Faculty of Dentistry, University of Debrecen , Debrecen, Hungary.
Gyorgy PanyiDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen, Hungary.
University of Debrecen · HUMiltenyi Biotec (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ion channels play pivotal role in the physiological and pathological function of immune cells. As immune cells represent a functionally diverse population, subtype-specific functional studies, such as single-cell electrophysiology require proper subset identification and separation. Magnetic-activated cell sorting (MACS) techniques provide an alternative to fluorescence-activated cell sorting (FACS), however, the potential impact of MACS-related beads on the biophysical and pharmacological properties of the ion channels were not studied yet. We studied the aforementioned properties of the voltage-gated Kv1.3 K

Indexed as

Immunomagnetic SeparationKv1.3 Potassium ChannelCD4-Positive T-LymphocytesHumansPatch-Clamp TechniquesKv1.3 Potassium Channelcd4+ T-cellfacsfluorescence-activated cell sortingimmunomagnetic separationKv1.3macsmagnetic-activated cell sorting

Identifiers

PMID33356811
PMCPMC7781520
OpenAlexW3102869994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.