Evidence map›Paper›PMID 33356653›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Inhibition of the β-carbonic anhydrase from the protozoan pathogen

Linda J Urbański, Andrea Angeli, Vesa P Hytönen, Anna Di Fiore, Giuseppina De Simone, Seppo Parkkila, Claudiu T Supuran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Activation of the β-carbonic anhydrase from the protozoan pathogenJournal of enzyme inhibition and medicinal chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Linda J UrbańskiFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Andrea AngeliNeurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Firenze, Italy.ORCID https://orcid.org/0000-0002-1470-7192
Vesa P HytönenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Anna Di FioreInstitute of Biostructures and Bioimaging of the National Research Council, Naples, Italy.
Giuseppina De SimoneInstitute of Biostructures and Bioimaging of the National Research Council, Naples, Italy.
Seppo ParkkilaFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID https://orcid.org/0000-0001-7323-8536
Claudiu T SupuranNeurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Firenze, Italy.ORCID https://orcid.org/0000-0003-4262-0323
Tampere University · FIInstitute of Biostructure and Bioimaging · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulphonamides and their isosteres are classical inhibitors of the carbonic anhydrase (CAs, EC 4.2.1.1) metalloenzymes. The protozoan pathogen

Indexed as

Antiprotozoal AgentsBinding SitesCarbonic AnhydrasesDrug RepositioningDrugs, InvestigationalEscherichia coliEthoxzolamideGene ExpressionKineticsModels, MolecularPrescription DrugsProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsProtozoan ProteinsAntiprotozoal AgentsCarbonic AnhydrasesDrugs, InvestigationalEthoxzolamidePrescription DrugsProtozoan ProteinsRecombinant ProteinsSulfonamidesCarbonic anhydraseinhibitorsulphonamideTrichomonas vaginalistrichomoniasis

Identifiers

PMID33356653
PMCPMC7782162
OpenAlexW3114097398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.