Evidence map›Paper›PMID 33356404›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.

Roman Medvedev, Jose L Sanchez-Alonso, Anita Alvarez-Laviada, Stefano Rossi, Eef Dries, Tilo Schorn, Vahitha B Abdul-Salam, Natalia Trayanova, Beata Wojciak-Stothard, Michele Miragoli and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Right Heart Diastology, Where Are We Now?Circulation research · 2026
    Review
  2. Stretchable large-area transparent nanowire composite arrays for label-free multimodal interrogation of cardiac physiology.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Caveolae-associated cAMP/CaJournal of molecular and cellular cardiology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Roman MedvedevFrom the Dipartimento di Cardiochirurgia, Università degli Studi di Verona, Ospedale Borgo Trento, Italy (R.M., G.F.).
Jose L Sanchez-AlonsoNational Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).
Anita Alvarez-LaviadaNational Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).
Stefano RossiDipartimento di Medicina e Chirurgia, Università degli Studi di Parma, Italy (S.R., M.M.).
Eef DriesNational Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).
Tilo SchornHumanitas Clinical and Research Center, Rozzano, Italy (R.M., T.S., M.M.).
Vahitha B Abdul-SalamNational Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).
Natalia TrayanovaDepartment of Biomedical Engineering and Alliance for Cardiovascular Diagnostic and Treatment Innovation; Johns Hopkins University; Baltimore, MD (N.T.).
Beata Wojciak-StothardNational Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).
Michele MiragoliDipartimento di Medicina e Chirurgia, Università degli Studi di Parma, Italy (S.R., M.M.).
Giuseppe Faggian
Julia GorelikNational Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).
Imperial College London · GBUniversity of Parma · ITHumanitas University · ITJohns Hopkins University · USOspedale San Giuseppe · ITUniversity of Verona · IT

Funding

Infarct-related Ventricular Tachycardia Mechanisms: From Micro to ClinicalR01HL142496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2019 to 2022
$3.1M
Exploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8M
British Heart Foundation PG/15/69/31719British Heart Foundation RG/17/13/33173NHLBI NIH HHS R01 HL126802NHLBI NIH HHS R01 HL142496
6 · The paper itself

Abstract

Pulmonary hypertension is a complex disorder characterized by pulmonary vascular remodeling and right ventricular hypertrophy, leading to right heart failure. The mechanisms underlying this process are not well understood. We hypothesize that the structural remodeling occurring in the cardiomyocytes of the right ventricle affects the cytosolic Ca

Indexed as

AnimalsCalciumCalcium SignalingHypertension, PulmonaryHypertrophy, Right VentricularMaleMonocrotalineMyocytes, CardiacRatsRats, Sprague-DawleyVascular RemodelingCalciumMonocrotalinecalciumhypertensionmyocytes, cardiacphenotypevascular remodeling

Identifiers

PMID33356404
PMCPMC7855573
OpenAlexW3114177044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.