Evidence map›Paper›PMID 33356161›Full record

ArticleBiochemistry2021

Kinetic Effects of β,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA.

Noah A Setterholm, Pouya Haratipour, Boris A Kashemirov, Charles E McKenna, Gerald F Joyce

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Synthesis of 8-oxo-dGTP and its β,γ-CHTetrahedron letters · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Noah A SetterholmThe Salk Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, United States.
Pouya HaratipourDepartment of Chemistry, Dana and David Dornsife College of Letters, Arts, and Sciences, University of Southern California, University Park Campus, Los Angeles, California 90089, United States.ORCID 0000-0003-0181-8958
Boris A KashemirovDepartment of Chemistry, Dana and David Dornsife College of Letters, Arts, and Sciences, University of Southern California, University Park Campus, Los Angeles, California 90089, United States.
Charles E McKennaDepartment of Chemistry, Dana and David Dornsife College of Letters, Arts, and Sciences, University of Southern California, University Park Campus, Los Angeles, California 90089, United States.ORCID 0000-0002-3540-6663
Gerald F JoyceThe Salk Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-0603-2874
University of Southern California · USSalk Institute for Biological Studies · US

Funding

Molecular Mechanisms of Human DNA Polymerase Beta Catalysis, Fidelity and Selective InhibitionU19CA177547 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOODMAN, MYRON · 2013 to 2017
$5.5M
NCI NIH HHS U19 CA177547Science Planetary Science NASAShared Services Center NASA 80NSSC17K0462
6 · The paper itself

Abstract

A recently described DNA polymerase ribozyme, obtained by

Indexed as

DeoxyribonucleotidesDNADNA-Directed DNA PolymeraseHumansKineticsPolymerizationPolyphosphatesRNA, CatalyticDeoxyribonucleotidesDNADNA-Directed DNA PolymerasePolyphosphatesRNA, Catalytictriphosphoric acid

Identifiers

PMID33356161
PMCPMC8024617
OpenAlexW3116558730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.