Evidence map›Paper›PMID 33355902›Full record

ArticleInfectious diseases and therapy2021

The Effect of Single-Room Care Versus Open-Bay Care on the Incidence of Bacterial Nosocomial Infections in Pre-Term Neonates: A Retrospective Cohort Study.

Sophie J Jansen, Enrico Lopriore, Romy J M Berkhout, Alieke van der Hoeven, Barbara Saccoccia, Jonne M de Boer, Karin E Veldkamp, Martha T van der Beek, Vincent Bekker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious diseases and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sophie J JansenDivision of Neonatology, Department of Pediatrics, Willem Alexander Children's Hospital-Leiden University Medical Center (LUMC), Leiden, The Netherlands. s.j.jansen@lumc.nl.
Enrico LoprioreDivision of Neonatology, Department of Pediatrics, Willem Alexander Children's Hospital-Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Romy J M BerkhoutDivision of Neonatology, Department of Pediatrics, Willem Alexander Children's Hospital-Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Alieke van der HoevenDepartment of Medical Microbiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Barbara SaccocciaDivision of Neonatology, Department of Pediatrics, Willem Alexander Children's Hospital-Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Jonne M de BoerDivision of Neonatology, Department of Pediatrics, Willem Alexander Children's Hospital-Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Karin E VeldkampDepartment of Medical Microbiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Martha T van der BeekDepartment of Medical Microbiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Vincent BekkerDivision of Neonatology, Department of Pediatrics, Willem Alexander Children's Hospital-Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNosocomial infections (NIs) are a major source of iatrogenic harm in neonatal intensive care units (NICUs). The influence of the infrastructure of NICUs on NIs is not well documented. This study aims to examine the effect of single-room units (SRU) versus open-bay units (OBU) on the incidence of NIs, including central-line-associated bloodstream infections (CLABSI), in preterm neonates.

methodsAll preterm neonates (< 32 weeks gestational age) admitted to our NICU were included. Two study periods were compared: one prior to (May 2015-May 2017) and one following (May 2017-May 2019) transition from OBU to SRU. Incidence density (number of infections per 1000 patient-days) and cumulative incidence (number of infections per 100 neonates) for NIs were calculated. CLABSIs were calculated per 1000 central-line days. U chart analysis was performed to determine special-cause variation in quarterly CLABSI and NI rates. Multivariate competing risk regression was performed to identify independent NI risk factors.

resultsOf the 712 included infants, 164 (23%) infants acquired ≥ 1 NIs. No differences were found in incidence density (13.68 vs. 12.62, p = 0.62) or cumulative incidence of NI (23.97 vs. 22.02, p = 0.59) between OBU and SRU. CLABSIs showed a similar non-significant reduction after the move (14.00 vs. 10.59, p = 0.51). U chart analysis did not identify unit transition as a potential source of special-cause variation for CLABSI and NI. Competing risks regression analysis revealed longer duration of invasive mechanical ventilation as a significant risk factor for NI (subhazards ratio: 1.03 per day on ventilation, p = 0.01).

conclusionSingle-rooms are not associated with a significant reduction in NIs in the NICU. This study therefore does not add evidence that could support the transition to SRUs if based only on a large multimodal infection control strategy. Recommendations to build SRUs would require a wider justification, also taking into account other SRU benefits.

Indexed as

NeonatesNosocomial infectionsOpen-ward designSingle-room units

Identifiers

PMID33355902
PMCPMC7756131
OpenAlexW3116838524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.