ArticleMolecular biology and evolution2021
Acoel Single-Cell Transcriptomics: Cell Type Analysis of a Deep Branching Bilaterian.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Revisiting nerve nets: functional organization and evolutionary implications.The EMBO journal · 2026Review
- Absence of conserved immune signalling pathways and increased pathogen susceptibility associated to photosymbiosis in acoels.BMC biology · 2026Article
- Establishing single cell RNA transcriptomics: a brief guide.Frontiers in zoology · 2025Review
- Genomics Sheds New Light on the Ancestral Bilaterian Opsin Repertoire and Suggests Rhabdomeric Phototransduction in Xenacoelomorpha.Genome biology and evolution · 2025Article
- A Phylogenomic Backbone for Acoelomorpha Inferred From Transcriptomic Data.Systematic biology · 2025Article
- The Acoel nervous system: morphology and development.Neural development · 2024Review
- Annelid adult cell type diversity and their pluripotent cellular origins.Nature communications · 2024Article
- Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity.Nature communications · 2024Article
- Structure of putative epidermal sensory receptors in an acoel flatworm, Praesagittifera naikaiensis.Cell and tissue research · 2024Article
- Marine Invertebrates One Cell at A Time: Insights from Single-Cell Analysis.Integrative and comparative biology · 2023Review
- Functional genomics in Spiralia.Briefings in functional genomics · 2023Article
- Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells.Nature communications · 2023Article
- Article
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
- Transgenesis in the acoel worm Hofstenia miamia.Developmental cell · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
Bilaterian animals display a wide variety of cell types, organized into defined anatomical structures and organ systems, which are mostly absent in prebilaterian animals. Xenacoelomorpha are an early-branching bilaterian phylum displaying an apparently relatively simple anatomical organization that have greatly diverged from other bilaterian clades. In this study, we use whole-body single-cell transcriptomics on the acoel Isodiametra pulchra to identify and characterize different cell types. Our analysis identifies the existence of ten major cell type categories in acoels all contributing to main biological functions of the organism: metabolism, locomotion and movements, behavior, defense, and development. Interestingly, although most cell clusters express core fate markers shared with other animal clades, we also describe a surprisingly large number of clade-specific marker genes, suggesting the emergence of clade-specific common molecular machineries functioning in distinct cell types. Together, these results provide novel insight into the evolution of bilaterian cell types and open the door to a better understanding of the origins of the bilaterian body plan and their constitutive cell types.
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