Evidence map›Paper›PMID 33355307›Full record

ArticleDiabetes2021

"Treasure Your Exceptions"-Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture.

Stephen O'Rahilly

3 registry-linked trialsOpen access · bronzeAbstract readLecture
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06080568 completednot on this mapstarted 2023, after this paper: background citation

Energy Balance and Mitochondrial Function in Human Genetic Models of Mitochondrial Stress-mediated Obesity Resistance

TypeobservationalSponsorRigshospitalet, DenmarkRan2023 to 2024Enrolled30ConditionsMitochondrial Diseases, Mitochondrial Myopathies, Mitochondrial Disorder
NCT06080581 completednot on this mapstarted 2023, after this paper: background citation

Mitochondrial Derangements Driving Muscle Insulin Resistance in Humans

TypeobservationalSponsorRigshospitalet, DenmarkRan2023 to 2024Enrolled30ConditionsMitochondrial Myopathies, Mitochondrial Diseases, Mitochondrial Disorders
NCT06080594 nacompletednot on this mapstarted 2024, after this paper: background citation

Exercise-mediated Rescue of Mitochondrial Derangements Driving Insulin Resistance in Humans (EX-MITO-DYS-IR)

TypeinterventionalSponsorRigshospitalet, DenmarkRan2024 to 2025Enrolled11ConditionsMitochondrial Myopathies, Mitochondrial Diseases, Mitochondrial DisordersArmsHigh-intensity exercise training
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Association of Mutations in theInternational journal of molecular sciences · 2026
    Pooled it
  2. Article
  3. Beyond Obesity.Medical sciences (Basel, Switzerland) · 2025
    Review
  4. Physiological protection against weight gain: evidence from overfeeding studies and future directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Stephen O'RahillyMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, University of Cambridge, Cambridge, U.K. so104@medschl.cam.ac.uk.ORCID 0000-0003-2199-4449
Wellcome/MRC Institute of Metabolic Science · GB

Funding

Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/1Wellcome TrustWellcome Trust 208363/Z/17/ZWellcome Trust 214274/Z/118/Z
6 · The paper itself

Abstract

The study of humans with genetic mutations which lead to a substantial disturbance of physiological processes has made a contribution to biomedical science that is disproportionate to the rarity of affected individuals. In this lecture, I discuss examples of where such studies have helped to illuminate two areas of human metabolism. First, the control of insulin sensitivity and its disruption in states of insulin resistance and second, the regulation of energy balance and its disturbances in obesity.

Indexed as

Insulin ResistanceMetabolic DiseasesPhenotypeAwards and PrizesHumansMutation

Identifiers

PMID33355307
PMCPMC7881844
OpenAlexW3113985128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.