Evidence map›Paper›PMID 33355247›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

Shilpa Thakur, Brianna Daley, Corina Millo, Craig Cochran, Orit Jacobson, Huiyan Lu, Zhantong Wang, Dale Kiesewetter, Xiaoyuan Chen, Vasyl Vasko and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Tailored Reaction Conditions and Automated Radiolabeling of [International journal of molecular sciences · 2025
    Article
  4. Preclinical safety and effectiveness of a long-acting somatostatin analogue [European journal of nuclear medicine and molecular imaging · 2025
    Article
  5. Article
  6. Article
  7. First preclinical evaluation of [EJNMMI radiopharmacy and chemistry · 2023
    Article
  8. Review
  9. Developments inFrontiers in chemistry · 2023
    Review
  10. New Biology of Pheochromocytoma and Paraganglioma.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Best Achievements in Clinical Thyroidology in 2020.Endocrinology and metabolism (Seoul, Korea) · 2021
    Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Shilpa ThakurMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.ORCID 0000-0003-3302-3412
Brianna DaleyMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.
Corina MilloClinical Center, NIH, Bethesda, Maryland.
Craig CochranMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.
Orit JacobsonMolecular Tracer and Imaging Core Facility, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, Maryland.
Huiyan LuNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.
Zhantong WangLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, Maryland.
Dale KiesewetterMolecular Tracer and Imaging Core Facility, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, Maryland.ORCID 0000-0002-7679-1465
Xiaoyuan ChenLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, Maryland.
Vasyl VaskoDepartment of Pediatric Endocrinology, Uniformed Services of the Health Sciences, Bethesda, Maryland.
Joanna Klubo-GwiezdzinskaMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland. joanna.klubo-gwiezdzinska@nih.gov.ORCID 0000-0001-8633-4420
National Institute of Diabetes and Digestive and Kidney Diseases · USNational Institute of Biomedical Imaging and Bioengineering · USNational Institutes of Health · USUniformed Services University of the Health Sciences · US

Funding

Molecular Tracer and Imaging Core FacilityZICEB000087 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI LANG, LIXIN · 2017 to 2025
$11.3M
Studies of Benign and Malignant Thyroid DiseaseZIADK047053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2009 to 2025
$4.3M
Somatostatin receptors in the diagnosis and treatment of thyroid cancerZIADK075138 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2017 to 2025
$3.8M
Intramural NIH HHS ZIA DK047053
6 · The paper itself

Abstract

purposeThe goal of this study was to analyze the role of somatostatin receptor type 2 (SSTR2) as a molecular target for the imaging and treatment of thyroid cancer through analysis of SSTR2 expression and its epigenetic modulation and testing tumor uptake of different radiolabeled SSTR2 analogues. EXPERIMENTAL

designWe analyzed SSTR2 expression by immunostaining of 92 thyroid cancer tissue samples and quantified standard uptake values (SUV

resultsThyroid cancer had a higher SSTR2 expression than normal thyroid. Hurthle cell thyroid cancer was characterized by the highest

conclusionsA novel SST analogue,

Indexed as

AdultAnimalsApoptosisCell ProliferationFemaleHumansMiceMice, Inbred NODMice, NudeMice, SCIDMiddle AgedNeoplasm MetastasisPositron Emission Tomography Computed TomographyPrognosisRadiopharmaceuticalsReceptors, Somatostatin(177)Lu-DOTA-EB-TATERadiopharmaceuticalsReceptors, SomatostatinSomatostatinSSTR2 protein, human

Identifiers

PMID33355247
PMCPMC9531406
OpenAlexW3118045428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.