ArticleScience advances2020
Digenic mutations in
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In one paragraph
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
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- From variants to answers: The evolution of genetic counseling in IEI.Journal of human immunity · 2026Review
- RNA damage signaling primes transcription-coupled repair.Nature structural & molecular biology · 2026Article
- Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis.Cell stem cell · 2026Article
- Systematic Druggable Genome-Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study.Health science reports · 2026Article
- Mechanisms of transcription-coupled repair and DNA damage surveillance in health and disease.Nature reviews. Molecular cell biology · 2026Review
- Genotoxic formaldehyde and lipid aldehydes are sources of DNA damage in keratinocytes.bioRxiv : the preprint server for biology · 2025Article
- A case of ADH5/ALDH2 deficiency combined with 3q29 microduplication syndrome.BMC pediatrics · 2025Article
- Transcription-coupled repair: tangled up in convoluted repair.The FEBS journal · 2025Review
- ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway.The Journal of cell biology · 2025Article
- Deficiency of the Fanconi anemia core complex protein FAAP100 results in severe Fanconi anemia.The Journal of clinical investigation · 2025Article
- Development and validation of tryptophan metabolism-related risk model and molecular subtypes for predicting postoperative biochemical recurrence in prostate cancer.Translational andrology and urology · 2025Article
- Novel FBN1 intron variant causes isolated ectopia lentis via in-frame exon skipping.Journal of human genetics · 2025Article
- Deciphering the cell type-specific and zonal distribution of drug-metabolizing enzymes, transporters, and transcription factors in livers of mice using single-cell transcriptomics.Drug metabolism and disposition: the biological fate of chemicals · 2025Article
- ADH5 inhibits proliferation but promotes EMT in non-small cell lung cancer cell through activating Smad2/Smad3.Open life sciences · 2025Article
- Formononetin Exerts Neuroprotection in Parkinson's Disease via the Activation of the Nrf2 Signaling Pathway.Molecules (Basel, Switzerland) · 2024Article
- Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging.Nucleic acids research · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 18 institutions in 1 country.
Yasuyoshi OkaDepartment of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.ORCID 0000-0002-0674-5578
Motoharu HamadaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-2473-3730
Yuka NakazawaDepartment of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.
Hideki MuramatsuDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yusuke OkunoDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0003-3139-9272
Koichiro HigasaDepartment of Genome Analysis, Institute of Biomedical Science, Kansai Medical University, Osaka, Japan.
Mayuko ShimadaDepartment of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.
Honoka TakeshimaDepartment of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.
Katsuhiro HanadaClinical Engineering Research Center, Faculty of Medicine, Oita University, Yufu, Japan.
Taichi HiranoDepartment of Hematology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.ORCID 0000-0003-0055-4591
Toshiro KawakitaDepartment of Hematology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Hirotoshi SakaguchiDepartment of Hematology and Oncology, Children Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.ORCID 0000-0003-0236-1187
Takuya IchimuraDepartment of Pediatrics, Graduate School of Medicine, Yamaguchi University, Ube, Japan.ORCID 0000-0002-7477-8689
Shuichi OzonoDepartment of Pediatrics and Child Health, School of Medicine, Kurume University, Kurume, Japan.ORCID 0000-0003-0009-9365
Kotaro YugeDepartment of Pediatrics and Child Health, School of Medicine, Kurume University, Kurume, Japan.ORCID 0000-0002-5801-7898
Yoriko WatanabeDepartment of Pediatrics and Child Health, School of Medicine, Kurume University, Kurume, Japan.ORCID 0000-0003-4685-8021
Yuko KotaniInstitute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan.
Mutsumi YamaneCenter for Animal Research and Education, Nagoya University, Nagoya, Japan.
Yumiko KasugaiDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID 0000-0003-4764-4455
Miyako TanakaDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.ORCID 0000-0002-5655-5633
Takayoshi SuganamiDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.ORCID 0000-0002-1918-0465
Shinichiro NakadaDepartment of Bioregulation and Cellular Response, Graduate School of Medicine, Osaka University, Osaka, Japan.ORCID 0000-0001-9297-1565
Norisato MitsutakeDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.ORCID 0000-0002-2744-8046
Yuichiro HaraDepartment of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.
Kohji KatoDepartment of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.ORCID 0000-0002-5704-2936
Seiji MizunoDepartment of Pediatrics, Aichi Developmental Disability Center, Kasugai, Japan.ORCID 0000-0002-1491-4124
Noriko MiyakeDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yosuke KawaiDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0666-1224
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-5501-0503
Masao NagasakiDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.ORCID 0000-0002-4292-8785
Seiji KitoCenter for Animal Research and Education, Nagoya University, Nagoya, Japan.
Keiichi IsoyamaDepartment of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan.
Masafumi OnoderaDivision of Immunology, National Center for Child Health and Development, Tokyo, Japan.
Hideo KanekoDepartment of Clinical Research, National Hospital Organization, Nagara Medical Center, Gifu, Japan.
Naomichi MatsumotoDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID 0000-0003-1761-6314
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tomoji MashimoInstitute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan.ORCID 0000-0001-7543-7301
Seiji KojimaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tomoo OgiDepartment of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan. togi@riem.nagoya-u.ac.jp.ORCID 0000-0002-5492-9072
Nagoya University · JPKurume University · JPAichi Cancer Center · JPKumamoto Medical Center · JPThe University of Osaka · JPThe University of Tokyo · JPTohoku University · JPYokohama City University · JPAichi Developmental Disability Center · JPJapanese Red Cross Nagoya Daiichi Hospital · JPKansai Medical University · JPKyoto University · JPNagara Medical Center · JPNagasaki University · JPNational Center For Child Health and Development · JPOita University · JPShowa University Fujigaoka Hospital · JPYamaguchi University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rs671 in the aldehyde dehydrogenase 2 gene (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.