Evidence map›Paper›PMID 33355124›Full record

ArticleScience advances2020

Network structure of the mouse brain connectome with voxel resolution.

Ludovico Coletta, Marco Pagani, Jennifer D Whitesell, Julie A Harris, Boris Bernhardt, Alessandro Gozzi

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 127 citations in OpenAlex.

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  6. Biophysical mechanisms of default mode network function and dysfunction.bioRxiv : the preprint server for biology · 2026
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  11. The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Reconfiguration of brain-wide neural activity after early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. The intrinsic neuronal network of the central nervous system and its modular (subsystem) architecture in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Reconfiguration of brain-wide neural activity after early life adversity.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Ludovico ColettaFunctional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.ORCID 0000-0001-8052-5154
Marco PaganiFunctional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.ORCID 0000-0002-6052-6931
Jennifer D WhitesellAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2961-5207
Julie A HarrisAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-0820-2021
Boris BernhardtMultimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Alessandro GozziFunctional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy. alessandro.gozzi@iit.it.ORCID 0000-0002-5731-4137
Allen Institute for Brain Science · USItalian Institute of Technology · ITMontreal Neurological Institute and Hospital · CAUniversity of Trento · IT

Funding

Mouse Cell Type-Specific Brain Mapping in Health and DiseaseR01AG047589 · NIA · ALLEN INSTITUTE · PI HARRIS, JULIE · 2014 to 2018
$3.4M
Neurobiological basis of dysconnectivity in a genetic risk model of psychosisR21MH116473 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GOZZI, ALESSANDRO · 2018 to 2019
$366k
NIA NIH HHS R01 AG047589NIMH NIH HHS R21 MH116473
6 · The paper itself

Abstract

Fine-grained descriptions of brain connectivity are required to understand how neural information is processed and relayed across spatial scales. Previous investigations of the mouse brain connectome have used discrete anatomical parcellations, limiting spatial resolution and potentially concealing network attributes critical to connectome organization. Here, we provide a voxel-level description of the network and hierarchical structure of the directed mouse connectome, unconstrained by regional partitioning. We report a number of previously unappreciated organizational principles in the mammalian brain, including a directional segregation of hub regions into neural sink and sources, and a strategic wiring of neuromodulatory nuclei as connector hubs and critical orchestrators of network communication. We also find that the mouse cortical connectome is hierarchically organized along two superimposed cortical gradients reflecting unimodal-transmodal functional processing and a modality-specific sensorimotor axis, recapitulating a phylogenetically conserved feature of higher mammals. These findings advance our understanding of the foundational wiring principles of the mammalian connectome.

Indexed as

ConnectomeAnimalsBrainMagnetic Resonance ImagingMammalsMiceNerve Net

Identifiers

PMID33355124
PMCPMC11206455
OpenAlexW3112138232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.