Evidence map›Paper›PMID 33355089›Full record

ArticleeLife2020

BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in

Laura Bel Borja, Flavie Soubigou, Samuel J P Taylor, Conchita Fraguas Bringas, Jacqueline Budrewicz, Pablo Lara-Gonzalez, Christopher G Sorensen Turpin, Joshua N Bembenek, Dhanya K Cheerambathur, Federico Pelisch

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Cortical microtubules oppose actomyosin-driven membrane ingression duringbioRxiv : the preprint server for biology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Zombies Never Die: The Double Life Bub1 Lives in Mitosis.Frontiers in cell and developmental biology · 2022
    Review
  12. Article
  13. Review
  14. PP2A Phosphatase as an Emerging Viral Host Factor.Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Laura Bel BorjaCentre for Gene Regulation and Expression, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID 0000-0002-8381-934X
Flavie SoubigouCentre for Gene Regulation and Expression, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Samuel J P TaylorCentre for Gene Regulation and Expression, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Conchita Fraguas BringasCentre for Gene Regulation and Expression, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID 0000-0001-9594-5856
Jacqueline BudrewiczLudwig Institute for Cancer Research, San Diego, United States.
Pablo Lara-GonzalezLudwig Institute for Cancer Research, San Diego, United States.
Christopher G Sorensen TurpinDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, United States.
Joshua N BembenekDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Dhanya K CheerambathurWellcome Centre for Cell Biology & Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Federico PelischCentre for Gene Regulation and Expression, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID 0000-0003-4575-1492
University of Dundee · GBUniversity of California San Diego · USUniversity of Michigan · USUniversity of Tennessee at Knoxville · USWellcome Centre for Cell Biology · GB

Funding

Kinetochore Specification and FunctionR01GM074215 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DESAI, ARSHAD · 2005 to 2025
$8.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Cell Cycle Regulation of Membrane TraffickingR01GM114471 · NIGMS · WAYNE STATE UNIVERSITY · PI BEMBENEK, JOSHUA NATHANIEL · 2015 to 2024
$2.6M
Medical Research Council MR/R008574/1NIGMS NIH HHS R01 GM074215NIGMS NIH HHS R01 GM114471NIH HHS P40 OD010440Wellcome Trust 105606/Z/14/ZWellcome Trust 208833Wellcome Trust 208833/Z/17/Z
6 · The paper itself

Abstract

Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore-microtubule attachments in yeast and mouse meiosis. In

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromosomesChromosome SegregationMeiosisOocytesProtein Phosphatase 2Protein Serine-Threonine Kinasesbub-1 protein, C elegansCaenorhabditis elegans ProteinsProtein Phosphatase 2Protein Serine-Threonine KinasesB56Bub1C. eleganscell biologymeiosisPP2ASLiM

Identifiers

PMID33355089
PMCPMC7787666
OpenAlexW3113938042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.