Evidence map›Paper›PMID 33354894›Full record

ArticleThe FEBS journal2021

Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase-dead mice.

Pavani Beesetty, Jananie Rockwood, Taku Kaitsuka, Tetyana Zhelay, Siham Hourani, Masayuki Matsushita, J Ashot Kozak

Open access · greenAbstract read
In one paragraph

Article in The FEBS journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Pavani BeesettyDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, USA.
Jananie RockwoodDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, USA.
Taku KaitsukaDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Japan.
Tetyana ZhelayDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, USA.
Siham HouraniDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, USA.
Masayuki MatsushitaDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
J Ashot KozakDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, USA.ORCID 0000-0002-7846-4759
Wright State University · USKumamoto University · JPUniversity of the Ryukyus · JP

Funding

TRPM7 and Cellular pHR01AI114804 · NIAID · WRIGHT STATE UNIVERSITY · PI KOZAK, JULIUSZ ASHOT · 2015 to 2019
$1.8M
PREP ScholarsR25GM086257 · NIGMS · WRIGHT STATE UNIVERSITY · PI CZERWINSKI, STEFAN A. · 2010 to 2013
$1.2M
NIAID NIH HHS R01 AI114804NIGMS NIH HHS R25 GM086257
6 · The paper itself

Abstract

Transient receptor potential melastatin 7 (TRPM7) is a unique protein functioning as a cation channel as well as a serine/threonine kinase and is highly expressed in immune cells such as lymphocytes and macrophages. TRPM7 kinase-dead (KD) mouse model has been used to investigate the role of this protein in immune cells; these animals display moderate splenomegaly and ectopic hemopoiesis. The basal TRPM7 current magnitudes in peritoneal macrophages isolated from KD mice were higher; however, the maximum currents, achieved after cytoplasmic Mg

Indexed as

AnimalsAntacidsCalcium SignalingCytosolHEK293 CellsHumansMacrophagesMagnesiumMicePhagocytesPhagocytosisSodium-Hydrogen Exchanger 1SpleenTRPM Cation ChannelsAntacidsMagnesiumSlc9a1 protein, mouseSodium-Hydrogen Exchanger 1Trpm7 protein, mouseTRPM Cation Channelsalkalinizationerythrophagocytosision channelSLC9A1spleen

Identifiers

PMID33354894
PMCPMC8184566
OpenAlexW3114260162

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.