ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Influenza Vaccine Effectiveness Against All-Cause Mortality Following Laboratory-Confirmed Influenza in Older Adults, 2010-2011 to 2015-2016 Seasons in Ontario, Canada.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of influenza vaccine effectiveness against laboratory-confirmed influenza among older adults living in aged care facilities.Human vaccines & immunotherapeutics · 2023Pooled it
- Primary Care Associated with Improved Life Expectancy in Older US Adults: A Retrospective Cohort Study of National Survey Data.Journal of general internal medicine · 2026Article
- Chronic disease prevalence and preventive care among Ontario social housing residents compared with the general population: a population-based cohort study.Journal of epidemiology and community health · 2025Article
- The Burden of All-Cause Mortality Following Influenza-Associated Hospitalizations: Influenza Hospitalization Surveillance Network, 2010-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- COVID-19 vaccination, all-cause mortality, and hospitalization for cancer: 30-month cohort study in an Italian province.EXCLI journal · 2025Article
- Safety Assessment of Influenza Vaccination for Neurological Outcomes Among Older Adults in Japan: A Self-Controlled Case Series Study.Pharmacoepidemiology and drug safety · 2025Observational
- Predictors of all-cause mortality among patients hospitalized with influenza, respiratory syncytial virus, or SARS-CoV-2.Influenza and other respiratory viruses · 2022Article
- Antigenic drift and epidemiological severity of seasonal influenza in Canada.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundOlder adults are at increased risk of mortality from influenza infections. We estimated influenza vaccine effectiveness (VE) against mortality following laboratory-confirmed influenza.
methodsUsing a test-negative design study and linked laboratory and health administrative databases in Ontario, Canada, we estimated VE against all-cause mortality following laboratory-confirmed influenza for community-dwelling adults aged >65 years during the 2010-2011 to 2015-2016 influenza seasons.
resultsAmong 54 116 older adults tested for influenza across the 6 seasons, 6837 died within 30 days of specimen collection. Thirteen percent (925 individuals) tested positive for influenza, and 50.6% were considered vaccinated for that season. Only 23.2% of influenza test-positive cases had influenza recorded as their underlying cause of death. Before and after multivariable adjustment, we estimated VE against all-cause mortality following laboratory-confirmed influenza to be 20% (95% confidence interval [CI], 8%-30%) and 20% (95% CI, 7%-30%), respectively. This estimate increased to 34% after correcting for influenza vaccination exposure misclassification. We observed significant VE against deaths following influenza confirmation during 2014-2015 (VE = 26% [95% CI, 5%-42%]). We also observed significant VE against deaths following confirmation of influenza A/H1N1 and A/H3N2, and against deaths with COPD as the underlying cause.
conclusionsThese results support the importance of influenza vaccination in older adults, who account for most influenza-associated deaths annually.
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