Evidence map›Paper›PMID 33354661›Full record

ReviewiScience2020

Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut.

Lauren R Heinzinger, Angus Johnson, Jenna I Wurster, Rachael Nilson, Swathi Penumutchu, Peter Belenky

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lauren R HeinzingerDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
Angus JohnsonDepartment of Biological Science, Binghamton University, Binghamton, NY 13902, USA.
Jenna I WursterDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
Rachael NilsonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
Swathi PenumutchuDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
Peter BelenkyDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
Brown University · USBinghamton University · USUniversity at Buffalo, State University of New York · US

Funding

Using Genomic Epidemiology to Identify Transmission Patterns and Inform Intervention Strategies for Antibiotic-Resistant N. GonorrhoeaeP20GM121344 · NIGMS · MIRIAM HOSPITAL · PI D'AGATA, ERIKA M · 2018 to 2022
$9.4M
Relating impacts of antibiotics on the gut metabolome and microbiome to host physiology and weight.R01DK125382 · NIDDK · BROWN UNIVERSITY · PI BELENKY, PETER · 2020 to 2024
$2.7M
Short-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9M
Predoctoral Training Program in Biological Data Science at Brown UniversityT32GM128596 · NIGMS · BROWN UNIVERSITY · PI RAMACHANDRAN, SOHINI, SANDSTEDE, BJORN · 2018 to 2022
$1.5M
Dietary fiber to mitigate antibiotic-induced microbiome dysbiosis: a multi-omics approachR21AT010366 · NCCIH · BROWN UNIVERSITY · PI BELENKY, PETER · 2019 to 2020
$447k
NCCIH NIH HHS R21 AT010366NHLBI NIH HHS R25 HL088992NIDDK NIH HHS R01 DK125382NIGMS NIH HHS P20 GM121344NIGMS NIH HHS T32 GM128596
6 · The paper itself

Abstract

Microbial metabolism is a major determinant of antibiotic susceptibility. Environmental conditions that modify metabolism, notably oxygen availability and redox potential, can directly fine-tune susceptibility to antibiotics. Despite this, relatively few studies have discussed these modifications within the gastrointestinal tract and their implication on

Indexed as

Microbial MetabolismMicrobiome

Identifiers

PMID33354661
PMCPMC7744946
OpenAlexW3109562555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.