Evidence map›Paper›PMID 33354643›Full record

ReviewJBMR plus2020

Controversies in Vitamin D: A Statement From the Third International Conference.

Andrea Giustina, Roger Bouillon, Neil Binkley, Christopher Sempos, Robert A Adler, Jens Bollerslev, Bess Dawson-Hughes, Peter R Ebeling, David Feldman, Annemieke Heijboer and 12 more

Open access · goldAbstract readReview
In one paragraph

Review in JBMR plus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 6 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 6 syntheses or guidelines pooled it, 178 citations in OpenAlex.

  1. Pooled it
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  7. Trial
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  11. OralNutrients · 2026
    Article
  12. Targeting the polyene chain represents an adjuvant strategy for optimizing polyene antifungals.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. 25-Hydroxyvitamin DCommunications medicine · 2026
    Article
  18. Article
  19. Article
  20. Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 20 institutions in 10 countries.

Andrea GiustinaInstitute of Endocrine and Metabolic Sciences, San Raffaele, Vita-Salute University and IRCCS Hospital Milan Italy.ORCID https://orcid.org/0000-0001-6783-3398
Roger BouillonLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases Metabolism and Ageing KU Leuven Leuven Belgium.ORCID https://orcid.org/0000-0002-6446-3763
Neil BinkleyOsteoporosis Clinical Research Program on Aging, University of Wisconsin Madison WI USA.ORCID https://orcid.org/0000-0002-9905-461X
Christopher SemposVitamin D Standardization Program LLC Havre de Grace MD USA.
Robert A AdlerMcGuire Veterans Affairs Medical Center and Virginia Commonwealth University School of Medicine Richmond VA USA.
Jens BollerslevSection of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, and Faculty of Medicine University of Oslo Oslo Norway.
Bess Dawson-HughesJean Mayer USDA Nutrition Research Center on Aging Tufts University Boston MA USA.ORCID https://orcid.org/0000-0003-3136-0386
Peter R EbelingDepartment of Medicine, School of Clinical Sciences Monash University Calyton Victoria Australia.ORCID https://orcid.org/0000-0002-2921-3742
David FeldmanDepartment of Medicine Stanford University School of Medicine Stanford CA USA.
Annemieke HeijboerEndocrine Laboratory, Department of Clinical Chemistry Amsterdam UMC, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam Gastroenterology & Metabolism Amsterdam The Netherlands.
Glenville JonesDepartment of Biomedical and Molecular Sciences Queen's University Kingston Ontario Canada.ORCID https://orcid.org/0000-0001-7402-3473
Christopher S KovacsFaculty of Medicine Memorial University of Newfoundland St. John's Newfoundland and Labrador Canada.ORCID https://orcid.org/0000-0002-5219-9993
Marise Lazaretti-CastroDivision of Endocrinology Escola Paulista de Medicina-Universidade Federal de Sao Paulo (EPM-UNIFESP) São Paulo Brazil.
Paul LipsDepartment of Internal Medicine, Endocrine Section Amsterdam University Medical Center Amsterdam The Netherlands.
Claudio MarcocciDepartment of Clinical and Experimental Medicine University of Pisa Pisa Italy.
Salvatore MinisolaDepartment of Internal Medicine and Medical Disciplines University of Rome "Sapienza" Rome Italy.ORCID https://orcid.org/0000-0001-6525-0439
Nicola NapoliUnit of Endocrinology and Diabetes Campus Bio-Medico, University of Rome Rome Italy.ORCID https://orcid.org/0000-0002-3091-8205
Rene RizzoliService of Bone Diseases Geneva University Hospitals and Faculty of Medicine Geneva Switzerland.
Robert ScraggSchool of Population Health University of Auckland Auckland New Zealand.
John H WhiteDepartment of Physiology McGill University Montreal Quebec Canada.
Anna Maria FormentiInstitute of Endocrine and Metabolic Sciences, San Raffaele, Vita-Salute University and IRCCS Hospital Milan Italy.
John P BilezikianDepartment of Medicine, Endocrinology Division, College of Physicians and Surgeons Columbia University New York NY USA.ORCID https://orcid.org/0000-0002-1570-2617
Vita-Salute San Raffaele University · ITAmsterdam Neuroscience · NLAmsterdam University Medical Centers · NLColumbia University · USGrace (United States) · USKU Leuven · BEMcGill University · CAMemorial University of Newfoundland · CAMonash University · AUOslo University Hospital · NOQueen's University · CASapienza University of Rome · ITStanford Medicine · USTufts University · USUniversidade Federal de São Paulo · BRUniversità Campus Bio-Medico · ITUniversity Hospital of Geneva · CHUniversity of Auckland · NZUniversity of Pisa · ITUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Third International Conference on Controversies in Vitamin D was held in Gubbio, Italy, September 10-13, 2019. The conference was held as a follow-up to previous meetings held in 2017 and 2018 to address topics of controversy in vitamin D research. The specific topics were selected by the steering committee of the conference and based upon areas that remain controversial from the preceding conferences. Other topics were selected anew that reflect specific topics that have surfaced since the last international conference. Consensus was achieved after formal presentations and open discussions among experts. As will be detailed in this article, consensus was achieved with regard to the following: the importance and prevalence of nutritional rickets, amounts of vitamin D that are typically generated by sun exposure, worldwide prevalence of vitamin D deficiency, the importance of circulating concentrations of 25OHD as the best index of vitamin D stores, definitions and thresholds of vitamin D deficiency, and efficacy of vitamin D analogues in the treatment of psoriasis. Areas of uncertainly and controversy include the following: daily doses of vitamin D needed to maintain a normal level of 25OHD in the general population, recommendations for supplementation in patients with metabolic bone diseases, cutaneous production of vitamin D by UVB exposure, hepatic regulation of 25OHD metabolites, definition of vitamin D excess, vitamin D deficiency in acute illness, vitamin D requirements during reproduction, potential for a broad spectrum of cellular and organ activities under the influence of the vitamin D receptor, and potential links between vitamin D and major human diseases. With specific regard to the latter area, the proceedings of the conference led to recommendations for areas in need of further investigation through appropriately designed intervention trials. © 2020 The Authors.

Indexed as

ENDOCRINE PATHWAYSMETABOLIC BONE DISEASESNUTRITIONOSTEOMALACIARICKETSVITAMIN DVITAMIN D DEFICIENCY

Identifiers

PMID33354643
PMCPMC7745884
OpenAlexW3090018289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.