Evidence map›Paper›PMID 33354577›Full record

ArticleJournal of immunology research2020

Defects at the Posttranscriptional Level Account for the Low TCR

Ana Aguinaga-Barrilero, Patricia Castro-Sánchez, Ignacio Juárez, Alberto Gutiérrez-Calvo, Noelia Rodríguez-Pérez, Adela Lopez, Remedios Gómez, José M Martin-Villa

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Hampered CD8 + ILT2 + T cell activation by HLA-G suggests a new immune checkpoint in gastric adenocarcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ana Aguinaga-BarrileroInmunología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
Patricia Castro-SánchezInmunología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
Ignacio JuárezInmunología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
Alberto Gutiérrez-CalvoServicio de Cirugía General y Aparato Digestivo, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Noelia Rodríguez-PérezInmunología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
Adela LopezServicio de Cirugía General y Aparato Digestivo, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Remedios GómezServicio de Cirugía General y Aparato Digestivo, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
José M Martin-VillaInmunología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0002-2436-8585
Universidad Complutense de Madrid · ESHospital Universitario Príncipe de Asturias · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReduced TCR

methodsT cell-enriched populations of blood or tissue (tumoral and nontumoral) origin from 44 patients with gastric adenocarcinoma and 33 healthy subjects were obtained. Samples were subjected to cytofluorimetry, Western blot analysis, TCR

resultsCytofluorimetry revealed a decreased TCR

conclusionsThese results further place the defect responsible for the low TCR

Indexed as

Gene Expression Regulation, NeoplasticRNA Processing, Post-TranscriptionalAdultAgedAged, 80 and overBiomarkersCaspase 3FemaleHumansImmunophenotypingLymphocyte ActivationMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Antigen, T-CellStomach Neoplasmsantigen T cell receptor, zeta chainBiomarkersCaspase 3Receptors, Antigen, T-Cell

Identifiers

PMID33354577
PMCPMC7737443
OpenAlexW3110088333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.