Evidence map›Paper›PMID 33354330›Full record

ArticleClinical kidney journal2020

Risk factors for severity of COVID-19 in chronic dialysis patients from a multicentre French cohort.

Guillaume Lano, Antoine Braconnier, Stanislas Bataille, Guilhem Cavaille, Julie Moussi-Frances, Bertrand Gondouin, Pascal Bindi, Magued Nakhla, Janette Mansour, Pascale Halin and 20 more

Open access · goldAbstract readComment
In one paragraph

Article in Clinical kidney journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  4. Meta-Analysis of Atrial Fibrillation in Patients With COVID-19.The American journal of cardiology · 2021
    Pooled it
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  9. Clinical manifestations of COVID-19 infection in dialysis patients and protective effect of COVID-19 vaccine.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 8 institutions in 1 country.

Guillaume LanoDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Antoine BraconnierDepartment of Nephrology and Renal Transplantation, Maison Blanche Hospital, University Hospital of Reims, Reims, France.
Stanislas BatailleAix-Marseille University, C2VN, INSERM 1263, INRAe 1260, Marseille, France.ORCID 0000-0001-8344-1300
Guilhem CavailleDIAVERUM, Saint Joseph Hospital, Marseille, France.
Julie Moussi-FrancesDIAVERUM, Saint Joseph Hospital, Marseille, France.
Bertrand GondouinDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Pascal BindiDepartment of Nephrology, Verdun Hospital, Verdun, France.
Magued NakhlaDepartment of Nephrology, Laon Hospital, Laon, France.
Janette MansourDepartment of Nephrology, Soissons Hospital, Soissons, France.
Pascale HalinDepartment of Nephrology, Charleville-Mézières Hospital, Charleville-Mézières, France.
Bénédicte LevyDepartment of Nephrology, Troyes Hospital, Troyes, France.
Eric CanivetAssociation Régionale pour la Promotion de la Dialyse à Domicile (ARPDD), Reims, France.
Khaled GahaDepartment of Nephrology and Renal Transplantation, Maison Blanche Hospital, University Hospital of Reims, Reims, France.
Isabelle KazesDepartment of Nephrology and Renal Transplantation, Maison Blanche Hospital, University Hospital of Reims, Reims, France.
Natacha NoelDepartment of Nephrology and Renal Transplantation, Maison Blanche Hospital, University Hospital of Reims, Reims, France.
Alain WynckelDepartment of Nephrology and Renal Transplantation, Maison Blanche Hospital, University Hospital of Reims, Reims, France.
Alexandre DebrumetzDepartment of Nephrology and Renal Transplantation, Maison Blanche Hospital, University Hospital of Reims, Reims, France.
Noemie Jourde-ChicheDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.ORCID 0000-0001-9315-1577
Valerie MoalDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Romain VialDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Violaine ScarfoglièreDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Mickael BobotDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Marion GullyDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Tristan LegrisDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Marion PelletierDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Marion SalleeDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Stephane BurteyDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.ORCID 0000-0003-1813-7884
Philippe BrunetDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Thomas RobertDepartment of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Marseille, France.
Philippe RieuDepartment of Nephrology and Renal Transplantation, Maison Blanche Hospital, University Hospital of Reims, Reims, France.
Assistance Publique Hôpitaux de Marseille · FRInserm · FRCentre Hospitalier Universitaire de Reims · FRHôpital Saint Joseph · FRCentre Hospitalier de Troyes · FRCentre National de la Recherche Scientifique · FRHôpital Manchester · FRLaboratoire de Physiologie et Génomique des Poissons · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) is an emerging infectious disease, related to severe acute respiratory syndrome coronavirus 2 infection. Few data are available in patients with end-stage renal disease (ESRD).

methodsWe conducted an observational cohort study of COVID-19 patients at 11 dialysis centres in two distinct districts of France to examine the epidemiological and clinical characteristics of COVID-19 in this population, and to determine risk factors of disease severity (defined as a composite outcome including intensive care unit admission or death) and mortality.

resultsAmong the 2336 patients enrolled, 5.5% had confirmed COVID-19 diagnosis. Of the 122 patients with a follow-up superior to 28 days, 37% reached the composite outcome and 28% died. Multivariate analysis showed that oxygen therapy on diagnosis and a decrease in lymphocyte count were independent risk factors associated with disease severity and with mortality. Chronic use of angiotensin II receptor blockers (ARBs) (18% of patients) was associated with a protective effect on mortality. Treatment with azithromycin and hydroxychloroquine (AZT/HCQ) (46% of patients) were not associated with the composite outcome and with death in univariate and multivariate analyses.

conclusionsCOVID-19 is a severe disease with poor prognosis in patients with ESRD. Usual treatment with ARBs seems to be protective of critical evolution and mortality. There is no evidence of clinical benefit with the combination of AZT/HCQ.

Indexed as

angiotensin II receptor blockersCOVID-19dialysishydroxychloroquinelymphocytes

Identifiers

PMID33354330
PMCPMC7743188
OpenAlexW3093605542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.