Evidence map›Paper›PMID 33353981›Full record

ReviewNature reviews. Molecular cell biology2021

NAD

Anthony J Covarrubias, Rosalba Perrone, Alessia Grozio, Eric Verdin

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 917 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
917citing papers in PubMed, 3 pooled it
69.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06465602 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls: a Pilot Randomized Clinical Trial

TypeinterventionalSponsorUniversity of ChileRan2024 to 2025Enrolled60ConditionsFrailty, Fall, Frailty Syndrome, FallsArmsNicotinamide, Placebo
NCT06567717 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Feasibility of a Decentralized Double-Blind Randomized Controlled Trial of Zinc and Nicotinamide Riboside for the Treatment of Idiopathic Pulmonary Fibrosis

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2025 to 2027Enrolled60ConditionsIdiopathic Pulmonary FibrosisArmsZinc, Placebos for zinc and nicotinamide riboside, Nicotinamide riboside
3 · Its place in the literature

Who cites it

917 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,370 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Domain-specific effects of NADFrontiers in nutrition · 2026
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Gut microbes · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Microvascular Dysfunction and Redox Imbalance in Long COVID.Microcirculation (New York, N.Y. : 1994) · 2026
    Article
  18. A sustained NADBioactive materials · 2026
    Article
  19. Review
  20. Article

857 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anthony J Covarrubias *Buck Institute for Research on Aging, Novato, CA, USA.
Rosalba Perrone *Buck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-8894-4548
Alessia Grozio *Buck Institute for Research on Aging, Novato, CA, USA.
Eric VerdinBuck Institute for Research on Aging, Novato, CA, USA. everdin@buckinstitute.org.ORCID http://orcid.org/0000-0003-3703-3183
Buck Institute for Research on Aging · USAtkins (United States) · US

Funding

REVERSIBLE MITOCHONDRIAL PROTEIN ACETYLATION AND METABOLIC REGULATIONR24DK085610 · NIDDK · J. DAVID GLADSTONE INSTITUTES · PI VERDIN, ERIC M. · 2010 to 2019
$16.0M
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
NIA NIH HHS T32 AG000266NIDDK NIH HHS R24 DK085610
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Indexed as

AgingCell Physiological PhenomenaMetabolic Networks and PathwaysAnimalsEnergy MetabolismHumansMitochondriaNADNAD

Identifiers

PMID33353981
PMCPMC7963035
OpenAlexW3115773653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.