ArticleNature chemistry2021
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine.
Article in Nature chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Leveraging Machine Learning for Accelerated Electrode-Electrolyte Interface Design in Rechargeable Li-Based Batteries.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
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- RobInHood: a robotic chemist in a fume hood.Digital discovery · 2026Article
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- Programmable Microwaveable Chemistry in the Chemputer.Angewandte Chemie (International ed. in English) · 2026Article
- Utilizing Similarity Measures to Map Chemical Reactivity.Angewandte Chemie (International ed. in English) · 2026Article
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- Universal peptide synthesis via solid-phase methods fused with chemputation.Nature communications · 2025Article
- Intelligent Systems for Inorganic Nanomaterial Synthesis.Nanomaterials (Basel, Switzerland) · 2025Review
- OCTOPUS: operation control system for task optimization and job parallelization via a user-optimal scheduler.Nature communications · 2024Article
- Article
- Automation and machine learning augmented by large language models in a catalysis study.Chemical science · 2024Review
- An integrated self-optimizing programmable chemical synthesis and reaction engine.Nature communications · 2024Article
- Transcription between human-readable synthetic descriptions and machine-executable instructions: an application of the latest pre-training technology.Chemical science · 2023Article
- Robotic Modules for the Programmable Chemputation of Molecules and Materials.ACS central science · 2023Review
- Chirality Sensing of N-Heterocycles viaJACS Au · 2023Article
- Digitizing chemical discovery with a Bayesian explorer for interpreting reactivity data.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Progress of Artificial Intelligence in Drug Synthesis and Prospect of Its Application in Nitrification of Energetic Materials.Molecules (Basel, Switzerland) · 2023Review
- Automated Library Generation and Serendipity Quantification Enables Diverse Discovery in Coordination Chemistry.Journal of the American Chemical Society · 2023Article
- The way to AI-controlled synthesis: how far do we need to go?Chemical science · 2022Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the automatic synthesis of molecules has been established, each reaction class uses bespoke hardware. This means that the connection of multi-step syntheses in a single machine to run many different protocols and reactions is not possible, as manual intervention is required. Here we show how the Chemputer synthesis robot can be programmed to perform many different reactions, including solid-phase peptide synthesis, iterative cross-coupling and accessing reactive, unstable diazirines in a single, unified system with high yields and purity. Developing universal and modular hardware that can be automated using one software system makes a wide variety of batch chemistry accessible. This is shown by our system, which performed around 8,500 operations while reusing only 22 distinct steps in 10 unique modules, with the code able to access 17 different reactions. We also demonstrate a complex convergent robotic synthesis of a peptide reacted with a diazirine-a process requiring 12 synthetic steps.
Identifiers
33353971What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.