Evidence map›Paper›PMID 33353937›Full record

ArticleNature communications2020

The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis.

Nick D Pokorzynski, Nathan D Hatch, Scot P Ouellette, Rey A Carabeo

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A conservedMicrobiology (Reading, England) · 2025
    Article
  6. Influence of cervicovaginal microbiota onMicrobial cell (Graz, Austria) · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Genome organization and genomics inFrontiers in cellular and infection microbiology · 2023
    Review
  13. Article
  14. The role of tryptophan inFrontiers in cellular and infection microbiology · 2022
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nick D PokorzynskiSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.ORCID 0000-0003-2438-2368
Nathan D HatchDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Scot P OuelletteDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-3721-6839
Rey A CarabeoDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA. rey.carabeo@unmc.edu.ORCID 0000-0002-5708-5493
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
Research Pilot Project ProgramP30GM106397 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI JOHNSON, KEITH R · 2013 to 2017
$4.9M
CHLAMYDIAL INVASION OF NON-PHAGOCYTIC CELLSR01AI065545 · NIAID · WASHINGTON STATE UNIVERSITY · PI CARABEO, REY A · 2005 to 2021
$3.3M
Regulatory Role of Tandem Tryptophan Codons in Chlamydial PersistenceR01AI132406 · NIAID · WASHINGTON STATE UNIVERSITY · PI CARABEO, REY A, OUELLETTE, SCOT P · 2019 to 2023
$2.9M
The molecular basis for integration of the Chlamydial responses to iron and tryptophan limitationF31AI136295 · NIAID · WASHINGTON STATE UNIVERSITY · PI POKORZYNSKI, NICHOLAS DAVID · 2018 to 2020
$94k
NCI NIH HHS P30 CA036727NIAID NIH HHS F31 AI136295NIAID NIH HHS R01 AI065545NIAID NIH HHS R01 AI132406NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P30 GM106397NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

The trp operon of Chlamydia trachomatis is organized differently from other model bacteria. It contains trpR, an intergenic region (IGR), and the biosynthetic trpB and trpA open-reading frames. TrpR is a tryptophan-dependent repressor that regulates the major promoter (P

Indexed as

Amino Acid MotifsBacterial ProteinsChlamydia trachomatisGene Expression Regulation, BacterialHeLa CellsHumansIndolesIronModels, BiologicalOperonPromoter Regions, GeneticProtein BiosynthesisProtein Domainsrho GTP-Binding ProteinsRNA, Transfer, TrpTranscription, GeneticBacterial ProteinsIndolesindolmycinIronrho GTP-Binding ProteinsRNA, Transfer, TrpTryptophan

Identifiers

PMID33353937
PMCPMC7755916
OpenAlexW3115237344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.