ArticleEuropean endodontic journal2020
Microbiological Investigation in Teeth with Persistent/Secondary Endodontic Infection in Different Stages of Root Canal Retreatment.
Article in European endodontic journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- The effect of apical preparation size and passive ultrasonic activation on microbial load in root canals with periapical lesions.Scientific reports · 2025Trial
- In vitro evaluation of the sealing ability of combined use of iRoot BP Plus and iRoot SP for root-end filling.Clinical oral investigations · 2023Trial
- Is apical periodontitis a matter of microbial diversity or time? A scoping review.Head & face medicine · 2026Article
- The conundrum of current endodontic disinfection strategies in microbial load reduction: a scoping review.BMC oral health · 2026Article
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Assessing Sealing Ability of C-Root SP Strontium Silicate Sealer With Different Obturation Techniques: An in vitro Study.International dental journal · 2026Article
- Regenerative Endodontic Procedure (REP) of a Previously Treated, Infected, Immature Permanent Incisor.Case reports in dentistry · 2026Article
- Antibacterial efficacy and molecular docking analysis ofJournal of conservative dentistry and endodontics · 2025Article
- Prevalence ofJournal of conservative dentistry and endodontics · 2025Article
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- Article
- Comparative evaluation of antimicrobial efficacy of different combinations of calcium hydroxide against Enterococcus faecalis.BMC oral health · 2023Article
- Comparative Evaluation of Antimicrobial Efficacy of Herbal Formulations of Septilin and Triphala with Conventional 2% Chlorhexidine on Root Canal and Oral Commensal Bacteria using Kirby Bauer Method: AnContemporary clinical dentistryArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present clinical study investigated the microbiota of teeth with persistent secondary endodontic infection in the different phases of root canal retreatment.
methodsTwenty filled single-rooted teeth with apical periodontitis were included. Samples were collected with sterile paper points before chemo-mechanical preparation (CMP) (S1), after CMP (S2) and after 30 days of calcium hydroxide-based intracanal medication (ICM) (S3). Cultivable bacteria were assessed by colony forming units count (CFU/mL). DNA was extracted and assessed by using nested PCR. Paired t-test and repeated measures ANOVA were applied for intragroup analysis in the stages of endodontic therapy at a significance level of 5%.
resultsCultivable bacteria were detected in all initial samples. CMP reduced bacteria by 99.4% and ICM by 99.5%. The most prevalent species found in the initial samples were E. faecalis (20/20), P. gingivalis (20/20), F. nucleatum (17/20) and A. actinomycetemcomitans (10/20), whereas D. pneumosintes, F. alocis, P. nigrescens and T. socranskii were not detected. After CMP, A. israelii, A. naeslundii, G. morbillorum, T. forsythia and T. denticola were not detected (P<0.05) either. E. faecalis and P. gingivalis had a low reduction (P>0.05) and F. nucleatum had its DNA significantly reduced after CMP (P<0.05). ICM had no additional effect on microbial reduction.
conclusionThe microbiota of teeth with persistent/secondary endodontic infection consists of a polymicrobial community with Gram-positive and Gram-negative species, bacillus and cocci, facultative and strict anaerobes. E. faecalis and P. gingivalis were frequently detected in all stages of root canal retreatment, evidencing their great resistance to endodontic procedures. The endodontic procedures were effective in reducing the levels of bacteria from teeth presenting with persistent/secondary endodontic infection.
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