Evidence map›Paper›PMID 33353668›Full record

ReviewBiological psychiatry2021

Understanding the Emergence of Social Anxiety in Children With Behavioral Inhibition.

Nathan A Fox, George A Buzzell, Santiago Morales, Emilio A Valadez, McLennon Wilson, Heather A Henderson

Open access · greenAbstract readReview
In one paragraph

Review in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review
  2. Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  8. Physical Freezing in Children and Adolescents with Selective Mutism.Behavioral sciences (Basel, Switzerland) · 2026
    Article
  9. A framework for infants' emerging affect-cognition interface.Current psychology (New Brunswick, N.J.) · 2026
    Article
  10. Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nathan A FoxDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, Maryland. Electronic address: fox@umd.edu.
George A BuzzellDepartment of Psychology, Florida International University, Miami, Florida.
Santiago MoralesDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, Maryland.
Emilio A ValadezDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, Maryland.
McLennon WilsonDepartment of Psychology, University of Waterloo, Waterloo, Ontario, Canada.
Heather A HendersonDepartment of Psychology, University of Waterloo, Waterloo, Ontario, Canada.
University of Maryland, College Park · USUniversity of Waterloo · CAFlorida International University · US

Funding

Trajectories of Behavioral Inibition and Risk for AnxietyU01MH093349 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2011 to 2020
$6.6M
The effects of early temperament on social behavior in adolescenceU01MH074454 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2009 to 2010
$1.3M
NIMH NIH HHS U01 MH074454NIMH NIH HHS U01 MH093349
6 · The paper itself

Abstract

Behavioral inhibition (BI) is a temperament characterized in early childhood by distress to novelty and avoidance of unfamiliar people, and it is one of the best-known risk factors for the development of social anxiety. However, nearly 60% of children with BI do not go on to meet criteria for social anxiety disorder. In this review we present an approach to understanding differential developmental trajectories among children with BI. We review research using laboratory-based tasks that isolate specific attention processes that enhance versus mitigate risk for social anxiety among behaviorally inhibited children and studies that suggest that BI is associated with heightened detection of novelty or threat. Moreover, stimulus-driven control processes, which we term "automatic control," increase the probability that behaviorally inhibited children display socially reticent behavior and develop social anxiety. In contrast, goal-driven control processes, which we term "planful control," decrease risk for anxiety. We suggest that these three categories of processes (detection, automatic control, and planful control) function together to determine whether behaviorally inhibited children are able to flexibly regulate their initial reactions to novelty, and in turn, decrease risk for social anxiety. Although laboratory-based tasks have identified these processes underlying risk and resilience, the challenge is linking them to the emotions, thoughts, and behaviors of behaviorally inhibited children in real-world contexts.

Indexed as

FearInhibition, PsychologicalAnxietyAnxiety DisordersChildChild, PreschoolHumansTemperamentAutomatic controlDevelopmental trajectoriesPlanful controlResponse to detectionSocial anxietyTemperament

Identifiers

PMID33353668
PMCPMC7954867
OpenAlexW3092279000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.