Evidence map›Paper›PMID 33353575›Full record

ArticleInternational psychogeriatrics2023

Generation and age of immigration on later life cognitive performance in KHANDLE.

Oanh L Meyer, Chloe W Eng, Michelle J Ko, Michelle L Chan, Uyen Ngo, Paola Gilsanz, M Maria Glymour, Elizabeth Rose Mayeda, Dan M Mungas, Rachel A Whitmer

Abstract read
In one paragraph

Article in International psychogeriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Discussing the Interplay of Social Determinants of Health, Aging, and Alzheimer's Biomarkers in U.S. Latinos.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Caregiving for Foreign-Born Older Adults With Dementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Oanh L MeyerDepartment of Neurology, University of California Davis Health, Sacramento, CA, USA.
Chloe W EngDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Michelle J KoDepartment of Public Health Sciences, University of California Davis, Davis, CA, USA.
Michelle L ChanDepartment of Neurology, University of California Davis Health, Sacramento, CA, USA.
Uyen NgoDepartment of Neurology, University of California Davis Health, Sacramento, CA, USA.
Paola GilsanzDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, CA, USA.
Dan M MungasDepartment of Neurology, University of California Davis Health, Sacramento, CA, USA.
Rachel A WhitmerDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Lifecourse health, cerebral pathology and ethnic disparities in dementiaRF1AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GLYMOUR, MEDELLENA MARIA · 2016 to 2016
$13.1M
UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Martha Jane Bailey · 2016 to 2026
$6.9M
Alzheimer’s disease and related dementias in a diverse cohort of Asian AmericansR01AG063969 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYEDA, ELIZABETH ROSE · 2019 to 2022
$2.0M
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaR01AG066132 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2019 to 2023
$2.0M
A Culturally-Relevant Approach to Reducing Dementia Caregiver Stress in an Underserved PopulationK01AG052646 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEYER, OANH L · 2016 to 2019
$515k
NCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR001860NIA NIH HHS K01 AG052646NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG063969NIA NIH HHS R01 AG066132NIA NIH HHS RF1 AG052132NICHD NIH HHS P2C HD041022
6 · The paper itself

Abstract

objectivesWe examined the association of generational status and age at immigration with later life cognitive outcomes in a diverse sample of Latinos and Asian Americans.

designBaseline data were obtained from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study, and a prospective cohort is initiated in 2017.

settingOlder adults in Northern California.

participantsOur cohort consisted of Asians ( MEASUREMENTS: We used multivariable linear regression models to estimate associations between generational status and age at immigration (collapsed into one five-level variable) with measures of verbal episodic memory, semantic memory, and executive function, adjusting for age, gender, race and ethnicity, and own- and parental education.

resultsGenerational status and age at immigration were associated with cognitive outcomes in a graded manner. Compared to third-generation or higher immigrants, first-generation immigration in adulthood was associated with lower semantic memory (β = -0.96; 95% CI: -1.12, -0.81) than immigration in adolescence (β = -0.68; 95% CI: -0.96, -0.41) or childhood (β = -0.28; 95% CI: -0.49, -0.06). Moreover, immigration in adulthood was associated with lower executive function (β = -0.63; 95% CI: -0.78, -0.48) than immigration in adolescence (β = -0.49; 95% CI: -0.75, -0.23). Similarly, compared to third-generation individuals, first-generation immigrants had lower executive functioning scores.

conclusionsOur study supports the notion that sociocontextual influences in early life impact later life cognitive scores. Longitudinal studies are needed to further clarify how immigration characteristics affect cognitive decline.

Indexed as

Healthy AgingMemory, EpisodicAgedChildCognitionEmigration and ImmigrationHumansLife Change EventsProspective Studiescognitiondiversitynativity statusrace/ethnicity

Identifiers

PMID33353575
PMCPMC8219806

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.