Evidence map›Paper›PMID 33353459›Full record

ArticleThyroid : official journal of the American Thyroid Association2021

Increased Hepatic Fat Content in Patients with Resistance to Thyroid Hormone Beta.

Carolina Chaves, Eveline Bruinstroop, Samuel Refetoff, Paul M Yen, João Anselmo

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Article
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  6. Article
  7. medRxiv : the preprint server for health sciences · 2026
    Article
  8. Review
  9. Article
  10. Article
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  15. Article
  16. Review
  17. Article
  18. Targeting THR-β for MASLD: Mechanisms and Drug Development.Drug design, development and therapy · 2025
    Review
  19. Actions of thyroid hormones and thyromimetics on the liver.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Carolina ChavesEndocrinologia e Nutrição, Hospital Divino Espirito Santo de Ponta Delgada, EPE, Açores, Portugal.
Eveline BruinstroopDepartment of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Samuel RefetoffDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.
Paul M YenCardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
João AnselmoEndocrinologia e Nutrição, Hospital Divino Espirito Santo de Ponta Delgada, EPE, Açores, Portugal.
Hospital do Divino Espírito Santo · PTDuke-NUS Medical School · SGDuke University · USUniversity of Chicago · US

Funding

THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
NIDDK NIH HHS R01 DK015070
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adipose TissueAdolescentAdultFatty LiverFemaleHumansInsulin ResistanceLiverMaleMiddle AgedMutationThyroid Hormone Receptors betaThyroid Hormone Resistance SyndromeYoung AdultThyroid Hormone Receptors betahepatic steatosisresistance to thyroid hormone betathyroid hormonestransient elastography

Identifiers

PMID33353459
PMCPMC8290309
OpenAlexW3113999992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.