Evidence map›Paper›PMID 33353109›Full record

ArticleCancers2020

Molecular Network Profiling in Intestinal- and Diffuse-Type Gastric Cancer.

Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  13. NCancers · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Shihori TanabeDivision of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki 210-9501, Japan.ORCID 0000-0003-3706-0616
Sabina QuaderInnovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki 210-0821, Japan.ORCID 0000-0002-9616-7408
Ryuichi OnoDivision of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki 210-9501, Japan.
Horacio CabralDepartment of Bioengineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-0033, Japan.
Kazuhiko AoyagiDepartment of Clinical Genomics, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Akihiko HiroseDivision of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki 210-9501, Japan.
Hiroshi YokozakiDepartment of Pathology, Kobe University of Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0001-5276-3331
Hiroki SasakiDepartment of Translational Oncology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
National Institute of Health Sciences · JPInnovation Center of NanoMedicine · JPKobe University · JPNational Cancer Centre Japan · JPThe University of Tokyo · JP

Funding

Japan Agency for Medical Research and Development (AMED) JP20ak0101093Japan Agency for Medical Research and Development (AMED) JP20jm0210059Japan Agency for Medical Research and Development (AMED) JP20mk0101163JSPS KAKENHI 18K19315Ministry of Health, Labour, and Welfare (MHLW) H30-KAGAKU-IPPAN-002
6 · The paper itself

Abstract

Epithelial-mesenchymal transition (EMT) plays an important role in the acquisition of cancer stem cell (CSC) feature and drug resistance, which are the main hallmarks of cancer malignancy. Although previous findings have shown that several signaling pathways are activated in cancer progression, the precise mechanism of signaling pathways in EMT and CSCs are not fully understood. In this study, we focused on the intestinal and diffuse-type gastric cancer (GC) and analyzed the gene expression of public RNAseq data to understand the molecular pathway regulation in different subtypes of gastric cancer. Network pathway analysis was performed by Ingenuity Pathway Analysis (IPA). A total of 2815 probe set IDs were significantly different between intestinal- and diffuse-type GC data in cBioPortal Cancer Genomics. Our analysis uncovered 10 genes including

Indexed as

cancer stem cellepithelial-mesenchymal transitionmolecular network

Identifiers

PMID33353109
PMCPMC7765985
OpenAlexW3109813370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.