Evidence map›Paper›PMID 33353096›Full record

ArticlePolymers2020

In Vitro and In Vivo Studies of Biodegradability and Biocompatibility of Poly(εCL)-

Ilya Nifant'ev, Andrey Shlyakhtin, Pavel Komarov, Alexander Tavtorkin, Evgeniya Kananykhina, Andrey Elchaninov, Polina Vishnyakova, Timur Fatkhudinov, Pavel Ivchenko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Marker-Independent Monitoring ofFrontiers in cardiovascular medicine · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Ilya Nifant'evChemistry Department, M.V. Lomonosov Moscow State University, 1-3 Leninskie Gory, 119991 Moscow, Russia.ORCID 0000-0001-9151-1890
Andrey ShlyakhtinChemistry Department, M.V. Lomonosov Moscow State University, 1-3 Leninskie Gory, 119991 Moscow, Russia.
Pavel KomarovA.V. Topchiev Institute of Petrochemical Synthesis RAS, 29 Leninsky Pr., 119991 Moscow, Russia.ORCID 0000-0003-4181-5022
Alexander TavtorkinA.V. Topchiev Institute of Petrochemical Synthesis RAS, 29 Leninsky Pr., 119991 Moscow, Russia.
Evgeniya KananykhinaResearch Institute of Human Morphology, 3 Tsyurupy St., 117418 Moscow, Russia.
Andrey ElchaninovNational Medical Research Center for Obstetrics Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Str., 117997 Moscow, Russia.
Polina VishnyakovaNational Medical Research Center for Obstetrics Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Str., 117997 Moscow, Russia.ORCID 0000-0001-8650-8240
Timur FatkhudinovResearch Institute of Human Morphology, 3 Tsyurupy St., 117418 Moscow, Russia.ORCID 0000-0002-6498-5764
Pavel IvchenkoChemistry Department, M.V. Lomonosov Moscow State University, 1-3 Leninskie Gory, 119991 Moscow, Russia.ORCID 0000-0002-0181-5952
A.V. Topchiev Institute of Petrochemical Synthesis · RULomonosov Moscow State University · RUNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation · RUNational Research University Higher School of Economics · RUPeoples' Friendship University of Russia · RUResearch Institute of Human Morphology · RU

Funding

Russian Science Foundation 16-13-10344
6 · The paper itself

Abstract

The control of surface bioadhesive properties of the subcutaneous implants is essential for the development of biosensors and controlled drug release devices. Poly(alkyl ethylene phosphate)-based (co)polymers are structurally versatile, biocompatible and biodegradable, and may be regarded as an alternative to poly(ethylene glycol) (PEG) copolymers in the creation of antiadhesive materials. The present work reports the synthesis of block copolymers of ε-caprolactone (εCL) and 2-ethoxy-1,3,2-dioxaphospholane-2-oxide (ethyl ethylene phosphate, EtOEP) with different content of EtOEP fragments, preparation of polymer films, and the results of the study of the impact of EtOEP/εCL ratio on the hydrophilicity (contact angle of wetting), hydrolytic stability, cytotoxicity, protein and cell adhesion, and cell proliferation using umbilical cord multipotent stem cells. It was found that the increase of EtOEP/εCL ratio results in increase of hydrophilicity of the polymer films with lowering of the protein and cell adhesion. MTT cytotoxicity test showed no significant deviations in toxicity of poly(εCL) and poly(εCL)-

Indexed as

cytotoxicityimmunohistochemical testpolycaprolactonepolyesterspolyphosphoestersprotein adsorptionring-opening polymerization

Identifiers

PMID33353096
PMCPMC7766882
OpenAlexW3112362159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.