Evidence map›Paper›PMID 33352956›Full record

ArticleInternational journal of molecular sciences2020

Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam.

Dorota Lachowicz, Agnieszka Kaczyńska, Anna Bodzon-Kulakowska, Anna Karewicz, Roma Wirecka, Michał Szuwarzyński, Szczepan Zapotoczny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. The Self-Assembly and Design of Polyfunctional Nanosystems.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dorota LachowiczAcademic Centre for Materials and Nanotechnology, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland.ORCID 0000-0001-9394-5297
Agnieszka KaczyńskaFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Anna Bodzon-KulakowskaDepartment of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland.ORCID 0000-0002-0158-8059
Anna KarewiczFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0001-9769-6240
Roma WireckaAcademic Centre for Materials and Nanotechnology, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland.ORCID 0000-0001-8089-5673
Michał SzuwarzyńskiAcademic Centre for Materials and Nanotechnology, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland.ORCID 0000-0002-9759-4372
Szczepan ZapotocznyFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0001-6662-7621

Funding

Narodowe Centrum Nauki 2014/15/D/ST4/02770
6 · The paper itself

Abstract

Low water solubility frequently compromises the therapeutic efficacy of drugs and other biologically active molecules. Here, we report on coacervate polysaccharide nanoparticles (CPNs) that can transport and release a model hydrophobic drug, piroxicam, to the cells in response to changes in temperature. The proposed, temperature-responsive drug delivery system is based on ionic derivatives of natural polysaccharides-curdlan and hydroxypropyl cellulose. Curdlan was modified with trimethylammonium groups, while the anionic derivative of hydroxypropyl cellulose was obtained by the introduction of styrenesulfonate groups. Thermally responsive nanoparticles of spherical shape and average hydrodynamic diameter in the range of 250-300 nm were spontaneously formed in water from the obtained ionic polysaccharides as a result of the coacervation process. Their morphology was visualized using SEM and AFM. The size and the surface charge of the obtained objects could be tailored by adjusting the polycation/polyanion ratio. Piroxicam (PIX) was effectively entrapped inside the nanoparticles. The release profile of the drug from the CPNs-PIX was found to be temperature-dependent in the range relevant for biomedical applications.

Indexed as

Drug Delivery SystemsAlgorithmsAnti-Inflammatory Agents, Non-SteroidalCelluloseChemistry Techniques, SyntheticDrug CarriersMicroscopy, Atomic ForceModels, TheoreticalMolecular StructureNanoparticlesPiroxicamPolyelectrolytesPolysaccharidesSpectrum AnalysisTemperatureAnti-Inflammatory Agents, Non-SteroidalCelluloseDrug CarriershydroxypropylcellulosePiroxicamPolyelectrolytesPolysaccharidescurdlandrug delivery systemhydroxypropyl cellulosepiroxicamself-organization

Identifiers

PMID33352956
PMCPMC7767055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.