Evidence map›Paper›PMID 33352938›Full record

ArticleBiomolecules2020

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes.

Theodora Panagaki, Elisa B Randi, Csaba Szabo

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Theodora PanagakiChair of Pharmacology, Section of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland.
Elisa B RandiChair of Pharmacology, Section of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland.
Csaba SzaboChair of Pharmacology, Section of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland.ORCID 0000-0003-3110-4235
University of Fribourg · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 179434
6 · The paper itself

Abstract

It is estimated that over 1.5 billion people suffer from various forms of chronic liver disease worldwide. The emerging prevalence of metabolic syndromes and alcohol misuse, along with the lack of disease-modifying agents for the therapy of many severe liver conditions predicts that chronic liver disease will continue to be a major problem in the future. Better understanding of the underlying pathogenetic mechanisms and identification of potential therapeutic targets remains a priority. Herein, we explored the potential role of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide (H

Indexed as

Endoplasmic Reticulum StressGene Expression RegulationAutophagyCell LineageCell SurvivalHepatocytesHep G2 CellsHumansHydrogen SulfideLiverMitochondriaSulfurtransferasesSuperoxidesThapsigarginTransfectionUnfolded Protein Response3-mercaptopyruvate sulphurtransferaseHydrogen SulfideSulfurtransferasesSuperoxidesThapsigarginautophagyER stresshepatic UPRhydrogen sulfidemitochondria

Identifiers

PMID33352938
PMCPMC7766142
OpenAlexW3111471822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.