ReviewBiology2020
The Influence of Eggshell on Bone Regeneration in Preclinical In Vivo Studies.
Review in Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- The potential of eggshell membrane in bone regeneration: a scoping review of applications and advances.The Saudi dental journal · 2026Review
- From Nutrition to Innovation: Biomedical Applications of Egg Components.Molecules (Basel, Switzerland) · 2025Review
- Sustainable synthesis of hydroxyapatite from poultry waste for veterinary applications: A calcination approach.Open veterinary journal · 2025Article
- Comparative evaluation of the effectiveness of a novel composite bone substitute synthesized from eggshell-derived hydroxyapatite and fish collagen in bone regeneration of critical-sized calvarial defects in Wistar rats.Frontiers in dental medicine · 2025Article
- A new eggshell-derived calcium phosphate bioceramic for tissue engineering: cytotoxicity and histomorphometric study.Acta cirurgica brasileira · 2025Article
- How Is Bone Regeneration Influenced by Polymer Membranes? Insight into the Histological and Radiological Point of View in the Literature.Membranes · 2024Review
- Comparison of the Eggshell and the Porcine Pericardium Membranes for Guided Tissue Regeneration Applications.Biomedicines · 2023Article
- Osteogenic stimulation of osteoprogenitors by putamen ovi peptides and hyaluronic acid.Head & face medicine · 2023Article
- Evaluation of Struthio camelus eggshell as an in vitro alternative to extracted human teeth in preliminary screening studies on dental erosion.Clinical and experimental dental research · 2023Article
- Biocompatibility and histological responses of eggshell membrane for dental implant-guided bone regeneration.Journal of medicine and life · 2023Article
- Characterization of eggshell as a bio-regeneration material.Medicine and pharmacy reports · 2023Article
- Article
- Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine.Polymers · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to systemically review the available evidence on the in vivo behavior of eggshell as a guided bone regeneration substitute material. Five databases (PubMed, Cochrane, Web of Science, Scopus, EMBASE) were searched up to October 2020. In vivo animal studies with a bone defect model using eggshell as a grafting material were included. Risk of bias was assessed using SYRCLE tool and the quality assessment using the ARRIVE guidelines. Overall, a total of 581 studies were included in the study, 187 after duplicate removal. Using the inclusion and exclusion criteria 167 records were further excluded. The full text of the remaining 20 articles was assessed for eligibility and included in the qualitative and quantitative assessment synthesis. There were different methods of obtaining eggshell grafting materials. Eggshell is a biocompatible grafting material, with osteoconduction proprieties. It forms new bone similar to Bio-Oss and demineralized freeze-dried bone matrix. It can be combined with other materials to enhance its proprieties. Due to the high variability of the procedures, animals, production and assessment methods, no meta-analysis could be performed. Eggshell might be considered a promising biomaterial to be used in bone grafting procedures, though further research is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.