ArticleDiagnostics (Basel, Switzerland)2020
Failure of Lactate Clearance Predicts the Outcome of Critically Ill Septic Patients.
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Sublingual microcirculatory assessment on admission independently predicts the outcome of old intensive care patients suffering from shock.Scientific reports · 2024Trial
- Acidemia predicts mortality independently of lactate levels in patients after cardiac arrest.Resuscitation plus · 2026Article
- Peak Lactate Within 24 h and Mortality in Septic Shock Patients Receiving Continuous Renal Replacement Therapy: A Real-World Cohort from an Asian ICU (2018-2020).Life (Basel, Switzerland) · 2025Article
- Generative AI mitigates representation bias and improves model fairness through synthetic health data.PLoS computational biology · 2025Article
- Hemoadsorption Therapy for Calcium Channel Blocker Overdose at a Tertiary-level Intensive Care Unit: A Retrospective Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- The value of blood lactate and lactate clearance rate in evaluating the prognosis of athletes with heat illness of varying degrees after high-intensity exercise.BMC sports science, medicine & rehabilitation · 2025Article
- Near-Infrared Spectroscopy (NIRS) to Assess Infection Complications During the Acute Phase of Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2024Article
- Prognostic value of hyperlactatemia and lactate clearance in septic patients with hematological malignancies.Annals of hematology · 2024Article
- Amiodarone Administration during Cardiopulmonary Resuscitation Is Not Associated with Changes in Short-Term Mortality or Neurological Outcomes in Cardiac Arrest Patients with Shockable Rhythms.Journal of clinical medicine · 2024Article
- Lactate Profile Assessment-A Good Predictor of Prognosis in Patients with COVID-19 and Septic Shock Requiring Continuous Renal Therapy.Clinics and practice · 2024Article
- Lactate Levels and Clearance: Key Predictors of Prognosis for COVID-19 and Non-COVID-19 Septic Shock Patients in the Emergency Department.Clinics and practice · 2024Article
- Hierarchical Capability in Distinguishing Severities of Sepsis via Serum Lactate: A Network Meta-Analysis.Biomedicines · 2024Review
- The impact of ethnic background on ICU care and outcome in sepsis and septic shock - A retrospective multicenter analysis on 17,949 patients.BMC infectious diseases · 2023Article
- Elevated Initial Serum Phosphate Levels Predict Higher Mortality and Impaired Neurological Outcome in Cardiac Arrest Patients with Return of Spontaneous Circulation.Diagnostics (Basel, Switzerland) · 2023Article
- Early Lactate Clearance as a Determinant of Survival in Patients with Sepsis: Findings from a Low-resource Country.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023Article
- The combination of lactate level, lactate clearance and APACHE II score better predicts short-term outcomes in critically Ill patients: a retrospective cohort study.BMC anesthesiology · 2022Article
- Multimodal Diagnostic Methods of Sepsis in Critically Ill Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Prediction of blood lactate values in critically ill patients: a retrospective multi-center cohort study.Journal of clinical monitoring and computing · 2022Article
- Relevance of pre-existing anaemia for patients admitted for acute coronary syndrome to an intensive care unit: a retrospective cohort analysis of 7418 patients.European heart journal open · 2022Article
- Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19.ESC heart failure · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEarly lactate clearance is an important parameter for prognosis assessment and therapy control in sepsis. Patients with a lactate clearance >0% might differ from patients with an inferior clearance in terms of intensive care management and outcomes. This study analyzes a large collective with regards to baseline risk distribution and outcomes.
methodsIn total, 3299 patients were included in this analysis, consisting of 1528 (46%) ≤0% and 1771 (54%) >0% patients. The primary endpoint was intensive care unit (ICU) mortality. Multilevel logistic regression analyses were used to compare both groups: A baseline model (model 1) with lactate clearance as a fixed effect and ICU as a random effect was installed. For model 2, patient characteristics (model 2) were included. For model 3, intensive care treatment (mechanical ventilation and vasopressors) was added to the model. Models 1 and 2 were used to evaluate the primary and secondary outcomes, respectively. Model 3 was only used to evaluate the primary outcomes. Adjusted odds ratios (aORs) with respective 95% confidence intervals (CI) were calculated.
resultsThe cohorts had no relevant differences regarding the gender, BMI, age, heart rate, body temperature, and baseline lactate. Neither the primary infection focuses nor the ethnic background differed between both groups. In both groups, the most common infection sites were of pulmonary origin, the urinary tract, and the gastrointestinal tract. Patients with lactate clearance >0% evidenced lower sepsis-related organ failure assessment (SOFA) scores (7 ± 6 versus 9 ± 6;
conclusionIn this large collective of septic patients, the 6 h lactate clearance is an independent method for outcome prediction.
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