ReviewMolecules (Basel, Switzerland)2020
Bioorthogonal Reactions in Activity-Based Protein Profiling.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Spatial proteomics in precision medicine: technologies, bioinformatics, and translational applications.Precision clinical medicine · 2026Review
- Navigating Solute Carrier Transporters-A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization.Medicinal research reviews · 2026Review
- Interfering Transposable Elements: ISXoo15 Transposase as a First-in-Class Antibacterial Target Against Xanthomonas oryzae pv. oryzae.Molecular plant pathology · 2025Article
- Taxonomic and mechanistic insights into gut microbiota bioaccumulation of entacapone using bioorthogonal drug labelling.Microbiome research reports · 2025Article
- Applications of Diels-Alder Chemistry in Biomaterials and Drug Delivery.Macromolecular bioscience · 2024Review
- Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities.Environmental microbiome · 2024Article
- The linkage-type and the exchange molecule affect the protein-labeling efficiency of iminoboronate probes.Organic & biomolecular chemistry · 2023Article
- Activity-based protein profiling: A graphical review.Current research in pharmacology and drug discovery · 2023Review
- Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling.Communications biology · 2022Article
- Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activitiesRSC chemical biology · 2022Article
- Detection of Bacterial α-l-Fucosidases with anMolecules (Basel, Switzerland) · 2022Article
- Modern Wound Dressings: Hydrogel Dressings.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Activity-based protein profiling (ABPP) is a powerful technique to label and detect active enzyme species within cell lysates, cells, or whole animals. In the last two decades, a wide variety of applications and experimental read-out techniques have been pursued in order to increase our understanding of physiological and pathological processes, to identify novel drug targets, to evaluate selectivity of drugs, and to image probe targets in cells. Bioorthogonal chemistry has substantially contributed to the field of ABPP, as it allows the introduction of tags, which may be bulky or have unfavorable physicochemical properties, at a late stage in the experiment. In this review, we give an overview of the bioorthogonal reactions that have been implemented in ABPP, provide examples of applications of bioorthogonal chemistry in ABPP, and share some thoughts on future directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.