Evidence map›Paper›PMID 33352764›Full record

ReviewPharmaceutics2020

Pharmacogenetic Testing: A Tool for Personalized Drug Therapy Optimization.

Kristina A Malsagova, Tatyana V Butkova, Arthur T Kopylov, Alexander A Izotov, Natalia V Potoldykova, Dmitry V Enikeev, Vagarshak Grigoryan, Alexander Tarasov, Alexander A Stepanov, Anna L Kaysheva

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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  18. Precision, integrative medicine for pain management in sickle cell disease.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kristina A MalsagovaBiobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.ORCID 0000-0001-9404-1660
Tatyana V ButkovaBiobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.ORCID 0000-0001-5111-3863
Arthur T KopylovBiobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.ORCID 0000-0002-7199-372X
Alexander A IzotovBiobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.
Natalia V PotoldykovaInstitute of Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
Dmitry V EnikeevInstitute of Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
Vagarshak GrigoryanInstitute of Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
Alexander TarasovInstitute of Linguistics and Intercultural Communication, Sechenov University, 119992 Moscow, Russia.
Alexander A StepanovBiobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.ORCID 0000-0002-9113-9440
Anna L KayshevaBiobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.ORCID 0000-0003-4472-2016
Institute of Biomedical Chemistry · RUSechenov University · RU

Funding

Russian Science Foundation 19-14-00298
6 · The paper itself

Abstract

Pharmacogenomics is a study of how the genome background is associated with drug resistance and how therapy strategy can be modified for a certain person to achieve benefit. The pharmacogenomics (PGx) testing becomes of great opportunity for physicians to make the proper decision regarding each non-trivial patient that does not respond to therapy. Although pharmacogenomics has become of growing interest to the healthcare market during the past five to ten years the exact mechanisms linking the genetic polymorphisms and observable responses to drug therapy are not always clear. Therefore, the success of PGx testing depends on the physician's ability to understand the obtained results in a standardized way for each particular patient. The review aims to lead the reader through the general conception of PGx and related issues of PGx testing efficiency, personal data security, and health safety at a current clinical level.

Indexed as

genetic polymorphismpersonalized medicinepharmacogeneticspharmacogenetic test

Identifiers

PMID33352764
PMCPMC7765968
OpenAlexW3117111844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.