Evidence map›Paper›PMID 33352578›Full record

ArticleObesity facts2021

Hepatic Steatosis Is Associated with Elevated Serum Iron in Patients with Obesity and Improves after Laparoscopic Sleeve Gastrectomy.

Bingwei Ma, Hang Sun, Bing Zhu, Shilin Wang, Lei Du, Xingchun Wang, Shen Qu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity facts, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Bingwei MaDepartment of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Hang SunDepartment of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Bing ZhuDepartment of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Shilin WangDepartment of Liver and Gallbladder Surgery, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Lei DuDepartment of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Xingchun WangDepartment of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Shen QuDepartment of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China, qushencn@hotmail.com.
Shanghai Tenth People's Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIron is closely related to metabolism. However, the relationship between iron and hepatic steatosis has not been fully elucidated.

objectiveWe aimed to investigate the triangular relationship between iron and hepatic steatosis and laparoscopic sleeve gastrectomy (LSG) in patients with obesity.

methodsA total of 297 patients with obesity and 43 healthy individuals with a normal BMI were enrolled. Eighty-two patients underwent LSG. Anthropometrics, glucose-lipid metabolic markers, and hepatic steatosis assessed by FibroScan (CAP value and E value) were measured at baseline, and again at follow-up time intervals of 6 months and 1 year after surgery.

results(1) Iron was significantly higher in patients with obesity or overweight than in the individuals with normal BMI (8.18 ± 1.47 vs. 7.46 ± 0.99 mmol/L, p = 0.002). Iron was also higher in subjects with high blood pressure, dyslipidemia, and hyperuricemia than non-corresponding disorders (all p < 0.05). Moreover, iron was significantly higher in the severe than mild or moderate non-alcoholic fatty liver disease (NAFLD) group (p = 0.046 and 0.018). (2) Iron was positively associated with body weight, BMI, waist-to-hip ratio, uric acid, liver enzymes, postprandial blood glucose, fasting insulin, HOMA-IR, triglycerides, free fatty acid, and hepatic steatosis (CAP value), and negatively associated with high-density lipoprotein cholesterol (all p < 0.05). Iron was also positively associated with the visceral adipose area in patients with obesity and negatively associated with the subcutaneous adipose area in patients with overweight (all p < 0.05). (3) Iron levels and CAP values were decreased gradually 6 months and 1 year after surgery (all p < 0.05).

conclusionsOverall, our results indicated that iron is associated with hepatic steatosis in obesity. The iron level was significantly higher in patients with severe NAFLD than with mild or moderate NAFLD. LSG may reduce iron levels while improving fat deposition in the liver.

Indexed as

GastrectomyObesityAdolescentAdultAgedHumansIronLaparoscopyMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseWaist-Hip RatioYoung AdultIronHepatic fat depositionIronLaparoscopic sleeve gastrectomyObesity

Identifiers

PMID33352578
PMCPMC7983566
OpenAlexW3117909449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.