Evidence map›Paper›PMID 33352553›Full record

ArticleAudiology & neuro-otology2021

Histopathologic Evaluation of Intralabyrinthine Schwannoma.

Michael Bagattini, Alicia M Quesnel, Christof Röösli

Open access · hybridAbstract read
In one paragraph

Article in Audiology & neuro-otology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Michael BagattiniDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
Alicia M QuesnelDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Christof RöösliDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland, Christof.Roeoesli@usz.ch.
University of Zurich · CHHarvard University · US

Funding

NIDCD National Temporal Bone, Hearing and Balance Pathology Resource RegistryU24DC013983 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI LIBERMAN, M. CHARLES, QUESNEL, ALICIA M · 2014 to 2025
$6.5M
NIDCD NIH HHS U24 DC013983
6 · The paper itself

Abstract

objectivesThe aim of this study is to perform a histopathologic analysis of temporal bones with an intralabyrinthine schwannoma (ILS) in order to characterize its extension.

methodsArchival temporal bones with a diagnosis of sporadic schwannoma were identified. Both symptomatic and occult nonoperated ILS were included for further analysis.

resultsA total of 6 ILS were identified, with 4 intracochlear and 2 intravestibular schwannomas. All intracochlear schwannomas involved the osseous spiral lamina, with 2 extending into the modiolus. The intravestibular schwannomas were limited to the vestibule, but growth into the bone next to the crista of the lateral semicircular canal was observed in 1 patient.

conclusionsComplete removal of an ILS may require partial removal of the modiolus or bone surrounding the crista ampullaris as an ILS may extend into these structures, risking damage of the neuronal structures. Due to the slow growth of the ILS, it remains unclear if a complete resection is required with the risk of destroying neural structures hindering hearing rehabilitation with a cochlear implant.

Indexed as

Cochlear ImplantationCochlear ImplantsNeurilemmomaNeuroma, AcousticCochleaHumansCochlear implantHistopathologyIntralabyrinthine schwannomaVestibular schwannoma

Identifiers

PMID33352553
PMCPMC8217404
OpenAlexW3114954277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.