Evidence map›Paper›PMID 33352538›Full record

ArticlePhysics in medicine and biology2021

Magnetic resonance shear wave elastography using transient acoustic radiation force excitations and sinusoidal displacement encoding.

Lorne W Hofstetter, Henrik Odéen, Bradley D Bolster, Douglas A Christensen, Allison Payne, Dennis L Parker

Open access · greenAbstract read
In one paragraph

Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Magnetic Resonance Acoustic Radiation Force Imaging (MR-ARFI).Journal of magnetic resonance imaging : JMRI · 2025
    Review
  6. Article
  7. Image-Based Monitoring of Thermal Ablation.Bioengineering (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Simultaneous proton resonance frequency TMagnetic resonance in medicine · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lorne W HofstetterDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, United States of America.ORCID 0000-0003-0041-6711
Henrik OdéenDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, United States of America.ORCID 0000-0003-2055-9795
Bradley D BolsterSiemens Medical Solutions USA, Inc., Salt Lake City, Utah, United States of America.
Douglas A ChristensenDepartment of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America.
Allison PayneDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, United States of America.
Dennis L ParkerDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, United States of America.
University of Utah · USMedical Solutions · GB

Funding

Validation and translation of a non-invasive, MR-guided breast cancer therapyR37CA224141 · NCI · UNIVERSITY OF UTAH · PI PAYNE, ALLISON · 2018 to 2024
$3.7M
Non-Invasive MRI-Guided HIFU for Breast Cancer TherapyR01CA172787 · NCI · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2013 to 2017
$2.7M
Toward the next generation in transcranial MR-guided focused ultrasound: Innovations in thermal and acoustic model-based planning and monitoring for improved safety, efficacy and efficiencyR01EB028316 · NIBIB · UNIVERSITY OF UTAH · PI PARKER, DENNIS L, RIEKE, VIOLA · 2019 to 2022
$2.5M
Improved MRI temperature imaging using a subject-specific biophysical modelR01EB013433 · NIBIB · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2011 to 2014
$1.8M
Siemens MAGNETOM Prisma 3T MRI scannerS10OD018482 · OD · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2015 to 2015
$1.2M
Improved temperature and quantitative magnetic resonance imaging specific for hyperthermia treatment monitoring and assessmentF30CA228363 · NCI · UNIVERSITY OF UTAH · PI HOFSTETTER, LORNE WYATT · 2018 to 2023
$246k
Multi-point MR-ARFI for time-efficient volumetric tissue stiffness imagingR03EB023712 · NIBIB · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2017 to 2018
$151k
NCI NIH HHS F30 CA228363NCI NIH HHS R01 CA172787NCI NIH HHS R37 CA224141NIBIB NIH HHS R01 EB013433NIBIB NIH HHS R01 EB028316NIBIB NIH HHS R03 EB023712NIH HHS S10 OD018482
6 · The paper itself

Abstract

A magnetic resonance (MR) shear wave elastography technique that uses transient acoustic radiation force impulses from a focused ultrasound (FUS) transducer and a sinusoidal-shaped MR displacement encoding strategy is presented. Using this encoding strategy, an analytic expression for calculating the shear wave speed in a heterogeneous medium was derived. Green's function-based simulations were used to evaluate the feasibility of calculating shear wave speed maps using the analytic expression. Accuracy of simulation technique was confirmed experimentally in a homogeneous gelatin phantom. The elastography measurement was compared to harmonic MR elastography in a homogeneous phantom experiment and the measured shear wave speed values differed by less than 14%. This new transient elastography approach was able to map the position and shape of inclusions sized from 8.5 to 14 mm in an inclusion phantom experiment. These preliminary results demonstrate the feasibility of using a straightforward analytic expression to generate shear wave speed maps from MR images where sinusoidal-shaped motion encoding gradients are used to encode the displacement-time history of a transiently propagating wave-packet. This new measurement technique may be particularly well suited for performing elastography before, during, and after MR-guided FUS therapies since the same device used for therapy is also used as an excitation source for elastography.

Indexed as

Computer SimulationElasticity Imaging TechniquesAcousticsMagnetic Resonance SpectroscopyPhantoms, Imagingacoustic radiation forceelastographymagnetic resonance elastographyMRgFUSshear wave elastographytransient MREviscoelastic simulations

Identifiers

PMID33352538
PMCPMC8217474
OpenAlexW3118119064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.