Evidence map›Paper›PMID 33352384›Full record

ArticleLung cancer (Amsterdam, Netherlands)2021

The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.

Mei Jiang, Aline F Fares, Daniel Shepshelovich, Ping Yang, David Christiani, Jie Zhang, Kouya Shiraishi, Brid M Ryan, Chu Chen, Ann G Schwartz and 28 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung cancer (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 42 citations in OpenAlex.

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  5. Body mass index as a predictor of postoperative complications after anatomical lung resection.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2026
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  14. Association Between Body Mass Index and Survival in Patients with De Novo Metastatic Non-Small Cell Lung Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 8 countries.

Mei JiangDepartment of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Aline F FaresDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; Hospital de Base, São José do Rio Preto, São Paulo, Brazil.
Daniel ShepshelovichSackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ping YangMayo Clinic, Rochester, MI, USA.
David ChristianiEnvironmental Health Department, Harvard TH Chan School of Public Health and Harvard Medical School, Boston, MA, USA.
Jie ZhangDepartment of Cardiothoracic Surgery, University of Pittsburgh Medical Center, USA; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Kouya ShiraishiDivision of Genome Biology, National Cancer Research Institute, Tokyo, Japan.
Brid M RyanCentre for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
Chu ChenProgram in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology and Department of Otolaryngology: Head and Neck Surgery, University of Washington, Seattle, WA, USA.
Ann G SchwartzBarbara Ann Karmanos Cancer Institute, Wayne State University Detroit, MI, USA.
Adonina TardonIUOPA, University of Oviedo and CIBERESP, Oviedo, Spain.
Sanjay SheteUniversity of Texas MD Anderson Cancer Center, Texas, USA.
Matthew B SchabathH. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
M Dawn TeareUniversity of Sheffield, Sheffield, UK.
Loic Le MarchandUniversity of Hawaii Cancer Centre, Honolulu, HI, USA.
Zuo-Feng ZhangUniversity of California Los Angeles School of Public Health, CA, USA.
John K FieldThe Roy Castle Lung Cancer Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nancy DiaoEnvironmental Health Department, Harvard TH Chan School of Public Health and Harvard Medical School, Boston, MA, USA.
Juntao XieDepartment of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Takashi KohnoDivision of Genome Biology, National Cancer Research Institute, Tokyo, Japan.
Curtis C HarrisCentre for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
Angela S WenzlaffBarbara Ann Karmanos Cancer Institute, Wayne State University Detroit, MI, USA.
Guillermo Fernandez-TardonIUOPA, University of Oviedo and CIBERESP, Oviedo, Spain.
Yuanqing YeUniversity of Texas MD Anderson Cancer Center, Texas, USA.
Fiona TaylorUniversity of Sheffield, Sheffield, UK.
Lynne R WilkensUniversity of Hawaii Cancer Centre, Honolulu, HI, USA.
Michael DaviesThe Roy Castle Lung Cancer Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.
Yi LiuMayo Clinic, Rochester, MI, USA; PLA Hospital, Beijing, China.
Matt J BarnettCancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gary E GoodmanSwedish Cancer Institute, Seattle, WA, USA.
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Bernd HolleczekSaarland Cancer Registry, Saarbrücken, Germany.
Sera ThomasProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
M Catherine BrownDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Wei XuDepartment of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Electronic address: Wei.Xu@uhnresearch.ca.
Geoffrey LiuDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Departments of Medical Biophysics, Pharmacology and Toxicity, and IMS, University of Toronto, Toronto, ON, Canada. Electronic address: Geoffrey.liu@uhn.ca.
University of Toronto · CAFudan University Shanghai Cancer Center · CNHarvard University · USMayo Clinic · USNational Institutes of Health · USThe University of Texas MD Anderson Cancer Center · USUniversidad de Oviedo · ESUniversity of Hawaiʻi at Mānoa · USUniversity of Liverpool · GBUniversity of Sheffield · GBWayne State University · USFred Hutch Cancer Center · USGerman Cancer Research Center · DEKrebsregister Saarland · DELunenfeld-Tanenbaum Research Institute · CAMoffitt Cancer Center · USPrincess Margaret Cancer Centre · CATel Aviv University · ILUniversity of California, Los Angeles · USUniversity of Michigan · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Translating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos, Rayjean J. Hung · 2017 to 2026
$23.7M
Precision Medicine of CancerZIABC011492 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HARRIS, CURTIS · 2013 to 2025
$23.2M
THE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0M
The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
SPORE in Lung CancerP50CA119997 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GABRILOVICH, DMITRY I · 2008 to 2012
$11.0M
Genetic Determinants of Lung Cancer SurvivalR01CA084354 · NCI · MAYO CLINIC ROCHESTER · PI YANG, PING · 2001 to 2012
$4.0M
The Role of Catecholamines in Lung CancerZIABC011555 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RYAN, BRID · 2014 to 2021
$3.7M
Infrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9M
INFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORYUM1CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 2013 to 2017
$2.8M
Health and QOL among Long-Term Lung Cancer SurvivorsR01CA115857 · NCI · MAYO CLINIC ROCHESTER · PI YANG, PING · 2006 to 2010
$2.4M
DEVELOPMENT OF LUNG CANCER EPIDEMIOLOGY RESEARCHR03CA077118 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI YANG, PING · 1997 to 1998
–
NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA119997NCI NIH HHS R01 CA084354NCI NIH HHS R01 CA115857NCI NIH HHS R03 CA077118NCI NIH HHS U01 CA063673NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA209414NCI NIH HHS U19 CA203654NCI NIH HHS UM1 CA167462
6 · The paper itself

Abstract

introductionThe relationship between Body-Mass-Index (BMI) and lung cancer prognosis is heterogeneous. We evaluated the impact of sex, smoking and race on the relationship between BMI and overall survival (OS) in non-small-cell-lung-cancer (NSCLC).

methodsData from 16 individual ILCCO studies were pooled to assess interactions between BMI and the following factors on OS: self-reported race, smoking status and sex, using Cox models (adjusted hazard ratios; aHR) with interaction terms and adjusted penalized smoothing spline plots in stratified analyses.

resultsAmong 20,937 NSCLC patients with BMI values, females = 47 %; never-smokers = 14 %; White-patients = 76 %. BMI showed differential survival according to race whereby compared to normal-BMI patients, being underweight was associated with poor survival among white patients (OS, aHR = 1.66) but not among black patients (aHR = 1.06; p

conclusionUnderweight and obese female ever-smokers were associated with worse outcomes in White-patients. These BMI associations were not observed in Asian-patients and never-smokers. Black-patients had more favorable outcomes in the extremes of BMI when compared to White-patients. Body composition in Black-patients, and NSCLC subtypes more commonly seen in Asian-patients and never-smokers, may account for differences in these BMI-OS relationships.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsBody Mass IndexFemaleHumansMaleOverweightRisk FactorsSmokingBody mass indexInteractionLung cancerObesity

Identifiers

PMID33352384
PMCPMC8042597
OpenAlexW3107615104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.