Evidence map›Paper›PMID 33352324›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

High prevalence of occult thrombosis in cases of mild/moderate COVID-19.

Budong Chen, Chunguo Jiang, Bing Han, Chunshuang Guan, Gaoli Fang, Shuo Yan, Kexin Wang, Ligai Liu, Christopher P Conlon, Ruming Xie and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  16. COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
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  19. Real-World Analysis of Thromboembolic Events and Mortality of COVID-19 Outpatients in the United States.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Budong ChenThe Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Chunguo JiangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Bing HanThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Chunshuang GuanThe Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Gaoli FangDepartment of Otolaryngology Head and Neck Surgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Shuo YanThe Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Kexin WangThe Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Ligai LiuCenter of Liver Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Christopher P ConlonInfectious Diseases, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Ruming XieThe Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address: mingrux@163.com.
Rui SongThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address: rui.song@ccmu.edu.cn.
Capital Medical University · CNUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAn increasing number of reports have observed thrombosis in severe cases of COVID-19. The aim of this study was to evaluate the incidence of thromboembolism in mild/moderate cases of COVID-19. All of the patients had normal coagulation tests and none had any overt thrombotic complications. Our findings indicate that it is important to screen the thrombotic status of cases with mild/moderate COVID-19.

methodsBetween 11 June and 8 July 2020, 23 patients with mild/moderate COVID-19 pneumonia consented to having computed tomography pulmonary angiography (CPTA) and computed tomography venography (CTV) scans of the lungs and extremity veins. Doppler ultrasound (DUS) was also performed in all patients for screening. The incidence, clinical manifestations, laboratory examinations, imaging features, and prognosis, of patients with venous thromboembolism (VTE) were analyzed and compared with those of patients with COVID-19 pneumonia without VTE.

resultsNineteen patients (82.6%) had VTE, mainly distal limb thrombosis. Only one of the VTE patients was positive when screened by DUS; the other VTE patients were negative by DUS. All of the mild/moderate patients with VTE were screened by CTPA + CTV. Blood tests for inflammatory, coagulation, and biochemical, parameters were all within the normal range, except for WBC and LDH.

conclusionsWhen using CTV screening for DVT, we found that the incidence of thrombosis in patients with mild/moderate COVID-19 markedly increased to 82.6% (19/23). Screening for thrombosis is therefore important in patients with COVID-19. CTV is more sensitive than DUS for the detection of thrombosis. More research is now needed to evaluate the significance of thrombosis in COVID-19 pneumonia.

Indexed as

SARS-CoV-2AdultCOVID-19FemaleHumansMaleMiddle AgedPrevalenceTomography, X-Ray ComputedUltrasonography, DopplerVenous ThromboembolismCOVID-19Mild/moderate COVID-19Thrombotic complicationsVenous thromboembolism

Identifiers

PMID33352324
PMCPMC7749732
OpenAlexW3115392762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.