Evidence map›Paper›PMID 33352323›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale.

Djuro Kosanovic, Andrey I Yaroshetskiy, Natalia A Tsareva, Zamira M Merzhoeva, Natalia V Trushenko, Galina V Nekludova, Ralph Theo Schermuly, Sergey N Avdeev

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Djuro KosanovicI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Andrey I YaroshetskiyI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Natalia A TsarevaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Zamira M MerzhoevaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Natalia V TrushenkoI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Galina V NekludovaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Ralph Theo SchermulyUniversities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany.
Sergey N AvdeevI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. Electronic address: serg_avdeev@list.ru.
Sechenov University · RUGerman Center for Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio.

Indexed as

Thrombolytic TherapyAcute DiseaseAgedCOVID-19Heart FailureHumansMaleRecombinant ProteinsRespiratory Distress SyndromeSARS-CoV-2Tissue Plasminogen ActivatorRecombinant ProteinsTissue Plasminogen ActivatorAcute cor pulmonaleARDSCOVID-19Recombinant tissue plasminogen activatorSARS-CoV-2

Identifiers

PMID33352323
PMCPMC7833717
OpenAlexW3118060525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.