Evidence map›Paper›PMID 33352117›Full record

ArticleCell chemical biology2021

Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.

Amy Flor, Donald Wolfgeher, Jing Li, Leslyn A Hanakahi, Stephen J Kron

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amy FlorUniversity of Chicago, Department of Molecular Genetics and Cell Biology, 929 E. 57th Street W522A, Chicago, IL 60637, USA.
Donald WolfgeherUniversity of Chicago, Department of Molecular Genetics and Cell Biology, 929 E. 57th Street W522A, Chicago, IL 60637, USA.
Jing LiUniversity of Illinois Chicago, College of Pharmacy, Department of Pharmaceutical Sciences, Rockford, IL 61107, USA.
Leslyn A HanakahiUniversity of Illinois Chicago, College of Pharmacy, Department of Pharmaceutical Sciences, Rockford, IL 61107, USA.
Stephen J KronUniversity of Chicago, Department of Molecular Genetics and Cell Biology, 929 E. 57th Street W522A, Chicago, IL 60637, USA. Electronic address: skron@uchicago.edu.
University of Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Lipid signaling in cellular senescence and tissue agingR01AG069865 · NIA · UNIVERSITY OF CHICAGO · PI KRON, STEPHEN J. · 2020 to 2024
$1.8M
Targets of Reactive Lipid Species regulating DNA damage response and cell senescenceR01CA217182 · NCI · UNIVERSITY OF CHICAGO · PI KRON, STEPHEN J. · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA217182NIA NIH HHS R01 AG069865
6 · The paper itself

Abstract

Topoisomerase 1 (Top1) reversibly nicks chromosomal DNA to relax strain accumulated during transcription, replication, chromatin assembly, and chromosome condensation. The Top1 poison camptothecin targets cancer cells by trapping the enzyme in the covalent complex Top1

Indexed as

CamptothecinCell ProliferationCells, CulturedDNA Topoisomerases, Type IHumansLipid PeroxidationLipidsMaleMolecular StructureOxidative StressCamptothecinDNA Topoisomerases, Type ILipidsTOP1 protein, humanchemotherapyenzymologyoxidative stressproteomicstopoisomerases

Identifiers

PMID33352117
PMCPMC8206239
OpenAlexW3113955511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.